Giriş Amaç Yüksek irtifada yaşanan komplikasyonlardan biri olan Anoreksiya, çevresel durumu sinyallerde enerji durumunu belirleyen ve iştahı kontrol eden hipoksinin neden olduğu rahatsızlıklardan kaynaklanmaktadır. ...

Effect of chloroquine in chronic hypoxia-induced bowel damage

As a chemotherapeutic agent, cisplatin is an antineoplastic agent used in the treatment of various solid tumors such as lung, testicle and bladder cancer (Ezaki, Nishiumi, Azuma, & Yoshida, 2017; Salem, Helmi, & Assaf, ...

Objective: Hypoxia has an important role in the disruption of intestinal mucosal integrity because of inflammation and apoptosis induced by inflammatory cytokines such as TNF-α (Tumor necrosis factor-alpha), IL-6 and ...

Purpose: We aimed to evaluate the protective effect of melatonin (Mel) on experimental hepatatoxicity induced by cisplatin (Cis). Materials and Methods: A total of 40 Wistar Albino rats were used. Control group (n = 10) ...

Chronic hypoxia negatively affects male fertility by causing pathological changes in male reproductive system. However, underlying mechanisms of this damage are unknown. Chloroquine (CLQ) is an anti-inflammatory agent that ...

Amaç: Adriamisin (ADR) kanser türlerinde kullanılan kemoterapötik bir ilaç olarak bilinmektedir. ADR uyarılı kardiyomiyopati toksik özelliğinden dolayı ilacın kullanımını zorlaştırmaktadır. ADR uyarılı kardiyotoksisitede ...

The aim of this study is to investigate the therapeutic effects of Chloroquine (CLQ) against Adriamycin (ADR) induced hepatotoxicity. ADR is a chemotherapeutic agent used in the treatment of many cancer types, but it causes ...

Purpose: In this study, we aimed to determine the effects of autophagy inhibitor and activator on Cisplatin (Cis)-induced tissue damage. Materials and Methods: A total of 24 male Wistar albino rats were divided into 4 ...