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Investigation of the Effect of Chloroquine on Adriamcycin-Induced Kidney Damage
(2022)
Although Adriamycin (ADR) is an important anticancer drug used in chemotherapy, it causes nephrotoxicity. The inflammation pathway has an important role in ADR-induced nephrotoxicity. Chloroquine (CLQ), which is used as ...
Metotreksat Uyarılı Rat Testis Hasarında Timokinon'un Etkisi
(2022)
Giriş: Kemoterapi kanser tedavisinde kullanılmasıyla birlikte kemoterapi ilaçlarının yan etkileri de mevcuttur. Kemoterapide kullanılan ilaçlardan biri olan metotreksat (MTX) özellikle meme kanseri ve romatoid artritte ...
Mitigative effects of chloroquine treatment against hypoxia-induced intestinal injury: a histological and immunohistochemical study
(Türk Hijyen ve Deneysel Biyoloji Dergisi, 2022)
Objective: Hypoxia has an important role in the disruption of intestinal mucosal integrity because of
inflammation and apoptosis induced by inflammatory cytokines such as TNF-α (Tumor necrosis factor-alpha), IL-6 and ...
Protective effect of melatonin on cisplatin-induced liver injury in rats
(Cukurova Medical Journal, 2022)
Purpose: We aimed to evaluate the protective effect of melatonin (Mel) on experimental hepatatoxicity induced by cisplatin (Cis).
Materials and Methods: A total of 40 Wistar Albino rats were used. Control group (n = 10) ...
Chloroquine attenuates chronic hypoxia-induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model
(Wiley Online Library, 2022)
Chronic hypoxia negatively affects male fertility by causing pathological changes in male reproductive system. However, underlying mechanisms of this damage are unknown. Chloroquine (CLQ) is an anti-inflammatory agent that ...