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Comparison of the Acute and Cumulative Dose Administrations in Doxorubicin-induced Hepatotoxicity via Evaluation of the Histopathological Changes and Inflammation in Rats

Akin, Ali Tuğrul; Kaymak, Emin; Karabulut, Derya; Doğanyiğit, Züleyha; Ceylan, Tayfun; Toluk, Ayşe; Özdamar, Saim (Experimental and Applied Medical Science, 2020)

Doxorubicin (DOX) may lead to hepatotoxicity when administered chronically or in a high dose. The aim of this study is to determine dose–dependent effects of DOX in rat liver tissue. Thirty male Wistar albino rats were ...

Histological evaluation of the effects of rapamycin and 3-methyladenine on cisplatin-induced epididymal injury in rats

Ceylan, Tayfun; Karabulut, Derya; Öztürk, Emel; Akin, Ali Tuğrul; Kaymak, Emin; Yakan, Birkan (Cukurova Medical Journal, 2021)

Purpose: In this study, we aimed to determine the effects of autophagy inhibitor and activator on Cisplatin (Cis)-induced tissue damage. Materials and Methods: A total of 24 male Wistar albino rats were divided into 4 ...

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