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Öğe A new analytical approach for preconcentration, separation and determination of Pb(II) and Cd(II) in real samples using a new adsorbent: Synthesis, characterization and application(Elseiver, 2021) Altunay, Nail; Hazer, Baki; Tüzen, Mustafa; Elik, AdilA green and efficient analytical approach was reported for simultaneous preconcentration, and separation of Pb (II) and Cd(II) in water, vegetables, and barbecue samples by dispersive solid-phase microextraction prior to their determination using flame atomic absorption spectrometry. A new poly-3-hydroxy butyrate-polyvinyl triethyl ammonium chloride comb-type amphiphilic cationic block copolymer (PHBvbNCl) was synthesized and char acterized. Main variables such as pH, sorbent amount, adsorption time, eluent type, desorption time, and sample volume were optimized. Detection limits and working ranges for Pb(II) and Cd(II) were 0.03 ?g L-1, 0.15 ?g L-1, 0.1–250 ?g L-1 and 0.5–375 ?g L-1, respectively. Enhancement factor for Pb (II) and Cd (II) were 114 and 98. The adsorption capacity of PHBvbNCl for Pb(II) and Cd(II) was 175.2 mg g? 1 and 152.9 mg g? 1 . After the accuracy of the method was confirmed by the analysis of certified reference materials, it was successfully applied to real samples. Finally, the analytical performance of the present method was compared with other methods.Öğe A newly synthesized graft copolymer for magnetic solid phase microextraction of total selenium and its electrothermal atomic absorption spectrometric determination in food and water samples(Elsevier Sci Ltd, 2019) Acikkapi, Ayse Nihan; Tuzen, Mustafa; Hazer, BakiA newly synthesized polystyrene-g-polyoleic acid-g-polyethylene glycol graft copolymer (PoleS-PEG) was used as adsorbent in the solid phase microextraction of selenium ions by using electrothermal atomic absorption spectrometry (ETAAS). Neodymium magnet was used for separation of analyte ions. Various analytical parameters such as pH, adsorbent amount, mixing time, eluent solution, sample volume, etc. were optimized. The matrix effects of some cations and anions were also studied. The capacity of the adsorbent was found 11.5 mg g(-1). The preconcentration factor was found to be 50. The detection limit (LOD) and quantification limit (LOQ) were found 6.06 ng L-1 and 20 ng L-1, respectively. The calibration curve was linear in the range of 0.02-4.0 mu g L-1. Relative standard deviation was found 3.2%. The accuracy of the method was provided by using standard reference materials. The optimized method was successfully applied to natural water and food samples.Öğe Amphiphiles from Poly(3-hydroxyalkanoates)(2020) Hazer, BakiPolyhydroxyalkanoates (PHA) are biodegradable and biocompatible microbially produced natural polyesters. However, their hydrophobic character is a disadvantage for the direct use of these polyesters. The key to biocompatibility of biomedical implantable materials is to alter their surface in a way that minimizes hydrophobic interaction with the surrounding tissue. Therefore, hydrophilic groups have been introduced into PHA in order to obtain amphiphilic polymers. This chapter has focused on the chemically modified PHA with enhanced hydrophilic character as biomaterials for medical applications.Öğe Autoxidized Oleic Acid Bifunctional Macro Peroxide Initiators for Free Radical and Condensation Polymerization. Synthesis and Characterization of Multiblock Copolymers(Springer, 2019) Ayyildiz, Elif; Eren, Melike; Canbay, Hale Secilmis; Ashby, Richard D.; Hazer, BakiAutoxidation of unsaturated fatty acids gives fatty acid macroperoxide initiators containing two functionalities which can lead to free radical and condensation polymerizations in a single pot. The oleic acid macroperoxide initiator obtained by ecofriendly autoxidation (Pole4m) was used in both the free radical polymerization of styrene and the condensation polymerization with amine-terminated polyethylene glycol (PEGNH2) to obtain triblock branched graft copolymers. The narrow molar masses of the poly oleic acid-g-styrene (PoleS) and poly oleic acid-g-styrene-g-PEG (PoSG) graft copolymers were successfully obtained. The inclusion of oleic acid decreased the glass transition temperature of the polystyrene segment because of the plasticizing effect of oleic acid. In addition, a mechanical property of the copolymer was improved when compared with the pure PS. Structural characterization, morphology of the fracture surface, micelle formation, thermal analysis and molar masses of the obtained products were also evaluated.Öğe Beech (Fagus orientalis) wood modification through the incorporation of polystyrene-ricinoleic acid copolymer with Ag nanoparticles(Springer, 2022) Can, Ahmet; Sivrikaya, Hüseyin; Hazer, Baki; Palanti, SabrinaCellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.Öğe Biodegradable and biocompatible radiopaque iodinated poly-3-hydroxy butyrate: synthesis, characterization and in vitro/in vivo X-ray visibility(Springer, 2020) Erol, Arzu; Rosberg, Derya B. Hazer; Hazer, Baki; Goncu, Beyza S.Some novel radiopaque biodegradable and biocompatible iodinated polymers based on poly-3-hydroxy butyrate (PHB) were obtained. Following the attachment of diethanol amine to PHB, the hydroxyl ends were capped with 4-iodobenzoic acid and 2,3,5-tri-iodobenzoic acid. In this manner, tri-novel radiopaque polymers were obtained. The resulting polymers were structurally characterized by NMR technique. They were evaluated with respect to their possible use as radiopaque implant biomaterials indicating X-ray visibility in a noninvasive manner using routine X-ray absorption imaging techniques. These polymers exhibited good radiopacity with conventional imaging X-ray techniques in vivo. Additionally, biocompatibility of these iodinated polymers was also evaluated. There were no signs of infection or abscess formation on the surgical area. These novel radiopaque PHBs should be promising biomaterials for a new-generation radiopaque materials.Öğe Chemical Modification of Poplar Wood with Benzophenone Tetracarboxylic Di Methacrylates(2020) Can, Ahmet; Hazer, Baki; Sivrikaya, HüseyinAim of study: The aim of this study was to analyze the use of benzophenone tetracarboxylic di methacrylates material in wood modification process and the changes in poplar wood. Material and methods: Poplar wood (Populus euramericana) was impregnated with the hydroxyethyl (or glycidyl) methacrylate esters of 3,3,4,4-benzophenone tetracarboxylic dianhydride. The liquid esters were obtained by reaction of BTDA with hydroxy ethyl (BTD-H) (or glycidyl, BTD-G) methacrylate. The wood-BTD-H (and BTD-G) interaction was confirmed by the characteristic signals in Fourier-transform infrared (FT-IR) spectroscopy. The decay resistance and physical behaviour of the modified wood was investigated. Main results: The BDTA-H samples displayed less colour change than the BDTA-G samples. Before decay testing, mini-block samples were leached according to the European Committee for Standardization (EN 84 1997) standard, then control and modified samples were subjected to white-rot fungus (Trametes versicolor). Modification with BTD-G yielded a high improvement in decay resistance (68-72%). Highlights: In the esterification of the chemical, it is benefited only from the sun's rays without the need for high temperature and pressure.Öğe Chromium Speciation in Water Samples by Loading a New Sulfide-Containing Biodegradable Polymer Adsorbent in Tip of the Syringe System(Springer International Publishing Ag, 2019) Ali, Jamshed; Tuzen, Mustafa; Kazi, Tasneem G.; Hazer, BakiA new adsorbent poly-3-hydroxybutyrate-2-(dodecylthiocarbonothioylthio)-2-methylpropionate triester (PH-DTT-MPT) was first time loaded in a micropipette tip for speciation of chromium in different water samples. Total chromium (Cr), trivalent chromium (Cr-III), and hexavalent chromium (Cr-VI) in different natural water samples were determined by electrothermal atomic absorption spectrometry. Known concentration of Cr-III and Cr-VI was passed through a biodegradable polymer for investigation of the behavior of the newly used adsorbent. The newly used copolymer absorbed the Cr-III on surface of the PH-DTT-MPT at pH7.0, while Cr-VI was not adsorbed in desired pH value. After passing the real and standard solutions through the micropipette, then 2.0molL(-1) HCl was used for elution of Cr-III from the biodegradable polymer. Total Cr was calculated after reducing Cr-VI into Cr-III by specific concentration of hydroxy ammonium chloride (HONH2HCl). The concentration of Cr-VI in different natural water samples was estimated after back calculation of Cr-III from total chromium. Effect of analytical parameters like adsorbent, pH, eluent, sample volume, flow rates, and interfering ions was also studied. The LOD, LOQ, RSD, and EF of the developed method were calculated as 6.1ngL(-1), 20ngL(-1), 1.17%, and 90, respectively. Validation of developed method was checked by certified reference materials and spiking addition method. The developed method was successfully applied for determination of total Cr, Cr-III, and Cr-VI in various natural water ecosystems.Öğe Designing siRNA-conjugated plant oil-based nanoparticles for gene silencing and cancer therapy(Taylor & Francis Ltd, 2019) Anilmis, Nur Merve; Kara, Goknur; Kılıçay, Ebru; Hazer, Baki; Denkbas, Emir BakiIn this study, the anticancer activities of two siRNA carriers were compared using a human lung adenocarcinoma epithelial cell line (A549). Firstly, poly(styrene)-graft-poly(linoleic acid) (PS-g-PLina) and poly(styrene)-graft-poly(linoleic acid)-graft-poly(ethylene glycol) (PS-g-PLina-g-PEG) graft copolymers were synthesized by free-radical polymerization. PS-PLina and PS-PLina-PEG nanoparticles (NPs) were prepared by solvent evaporation method and were then characterized. The size was found as 150 +/- 10 nm for PS-PLina and 184 +/- 6 nm for PS-PLina-PEG NPs. The NPs were functionalized with poly(l-lysine) (PLL) for c-myc siRNA conjugation. siRNA entrapment efficiencies were found in the range of 4-63% for PS-PLina-PLL and 6-42% for PS-PLina-PEG-PLL NPs. The short-term stability test was realised for 1 month. siRNA release profiles were also investigated. In vitro anticancer activity of siRNA-NPs was determined by MTT, flow cytometry, and fluorescence microscopy analyses. Obtained findings showed that both NPs systems were promising as siRNA delivery tool for lung cancer therapy.Öğe Development of sensitive and accurate solid-phase microextraction procedure for preconcentration of As(III) ions in real samples(2021) Elik, Adil; Tüzen, Mustafa; Hazer, Baki; Kaya, Savaş; Katin, K.P; Altunay, NailWe synthesized the poly(methyl methacrylate-co-2-aminoethyl methacrylate (PMaema) amphiphilic copolymer in a form of solid phase adsorbent. Then it was used for separation, preconcentration and determination of trace amount of As(III) ions from foods and waters with hydride generation atomic absorption spectrometry. The PMaema was characterized by fourier transform infrared spectrometer and nuclear magnetic resonance spectrometer. The adsorption of As(III) to the PMaema was also supported using computational chemistry studies. The experimental parameters (pH, PMaema amount, adsorption time and ethanol volume) were optimized using a three-level Box–Behnken design with four experimental factors. We observed linear calibration curve for the PMaema amount in the 10–500 ng L?1 range (R2 = 0.9956). Limit of detection, preconcentration factor and sorbent capacity of PMaema were equal to 3.3 ng L?1, 100 and 75.8 mg g?1, respectively. The average recoveries (spiked at 50 ng L?1) changes in the range of 91.5–98.6% with acceptable relative standard deviation less than 4.3%. After validation studies, the method was successfully applied for separation, preconcentration and determination of trace amount of As(III) from foods and waters.Öğe Ecofriendly Autoxidation of Castor Oil/Ricinoleic Acid. Multifunctional Macroperoxide Initiators for Multi Block/Graft Copolymers(Wiley, 2019) Eren, Melike; Hazer, BakiEcofriendly autoxidation is a reaction of air oxygen with unsaturated organic molecules at room temperature. Castor oil and ricinoleic acid were ecofriendly autoxidized for 5 months to obtain castor oil macroperoxide with a Mn of 1935 g mol(-1) (Pcast5m) and the ricinoleic acid macroperoxide initiator (Prici5m) with a Mn of 1169 g mol(-1). Peroxide groups thermally initiated the free radical polymerization of methyl methacrylate (MMA), n-butyl methacrylate (nBMA), and styrene (S). Peroxide formation in the oxidized castor oil and ricinoleic acid was confirmed using iodometric analysis, elemental analysis, and differential scanning calorimetry technique. Peroxide decomposition in both macroperoxide initiators was observed at 166 degrees C for Prici5m and 170 degrees C for Pcast5m. Hydroxyl groups of Pcast5m were reacted with methacryloyl chloride to obtain methacrylated castor oil macroperoxide (PcastMA). The polymerization rates of the obtained macroinitiators were compared. The polymerization rate order is Pcast5m > Prici5m > PcastMA. Polymerization of styrene by PcastMA resulted in an increase in molar masses and an increase in the polymerization time while those of the styrene polymerization by Pcast5m and Prici5m remained constant. Carboxylic acid groups were reacted with amine-terminated polyethylene glycol (PEG), polydimethyl siloxane (PDMS), and polytetrahydrofuran (PTHF) while the hydroxyl functionality initiated the ring-opening polymerization of epsilon-caprolactone (CL). Prici-PEG-PMMA, Prici-PS-PDMS, Prici-PS-PTHF, Pcast-PS-PCL, Pcast-PCL-PMMA, and Pcast-PS-PnBMA multiblock copolymers were prepared and characterized using spectrometric, thermal, and stress-strain measurement techniques.Öğe Electrospinning of Fatty Acid-Based and Metal Incorporated Polymers for the Fabrication of Eco-Friendly Fibers(Wiley, 2022) Erdem, Çağlar; Işık, Tuğba; Horzum, Nesrin; Hazer, Baki; Demir, Mustafa M.Accumulation of plastic wastes occupies large space in gyres of the oceans called the 7th continent. This high-level concentration of toxic plastic wastes causes harmful consequences for marine life, therefore petroleum-originated plastics must be replaced (or at least partially) with natural resources. The environmental trends in material preparation promote the utilization of greener methods and materials when the limited primary sources are considered. Starting from the fatty acid macroperoxide initiators, synthesis of bio-based polymers using less commercial chemicals and stepwise green synthesis schemes could be possible in the near future. In this research, autoxidized vegetable oil initiators (castor, limonene, and soybean oil) containing metal nanoparticles (silver, platinum, and gold) are employed for free radical polymerization of vinyl monomers. The metal loaded and vegetable oil-based polymers are processed by electrospinning and end up with the successful fabrication of continuous fibers. Ag-loaded ricinoleic acid based polymers show notable antibacterial activity against Escherichia coli. This approach offers a remarkable minimization of the initiator consumption in the synthesis of such synthetic macromolecules as well as nanoparticle containing polymer composites while still maintaining the ease of processing. Transforming the obtained graft copolymers to electrospun nanofibers facilitates the use as support materials for antibacterial surfaces.Öğe Fungal inhibition and chemical characterization of wood treated with novel polystyrene-soybean oil copolymer containing silver nanoparticles(Elsevier Sci Ltd, 2018) Can, Ahmet; Sivrikaya, Huseyin; Hazer, BakiIn this study, Scots pine (Pinus sylvestris L.) samples were impregnated with autoxidized soybean oil polymer containing Ag nanoparticles (Agsbox) and polystyrene-soybean oil copolymer (AgPSsb) in order to inhibit white rot fungus (Trametes versicolor). Chemical changes of the impregnated specimens were characterized by FTIR techniques. The higher concentration of nano preservative resulted in higher weight percent gain (WPG) in the impregnated samples. The samples impregnated with 1.5% of Agsbox, had the highest WPG (2.98%). The silver nanocomposite-impregnated wood specimens improved the anti-fungal properties. In addition, treatment with 0.4% AgPSsb resulted in the lowest moisture content (23.4%) after decay tests. In the samples, the lowest weight loss (0.87%) due to fungal decay was observed with the use of 0.4 wt% of AgPSsb. Mass losses of Agsbox impregnated specimens at 1.5% and 0.04% were 2.86% and 4.61% respectively. The FTIR spectra of the specimens impregnated with the nanocomposites showed the impregnated components at the peaks of 2910 cm(-1) and 1714 cm(-1) in particular.Öğe Gold and Cobalt Oxide Nanoparticles Modified Poly-Propylene Poly-Ethylene Glycol Membranes in Poly (?-Caprolactone) Conduits Enhance Nerve Regeneration in the Sciatic Nerve of Healthy Rats(2021) Hazer, Baki; Hazer Rosberg, Derya Burcu; Stenberg, Lena; Dahlin, Lars B.Reconstruction of nerve defects is a clinical challenge. Autologous nerve grafts as the gold standard treatment may result in an incomplete restoration of extremity function. Biosynthetic nerve conduits are studied widely, but still have limitations. Here, we reconstructed a 10 mm sciatic nerve defect in healthy rats and analyzed nerve regeneration in poly (?-caprolactone) (PCL) conduits longitudinally divided by gold (Au) and gold-cobalt oxide (AuCoO) nanoparticles embedded in poly-propylene poly-ethylene glycol (PPEG) membranes (AuPPEG or AuCoOPPEG) and compared it with unmodified PPEG-membrane and hollow PCL conduits. After 21 days, we detected significantly better axonal outgrowth, together with higher numbers of activated Schwann cells (ATF3-labelled) and higher HSP27 expression, in reconstructed sciatic nerve and in corresponding dorsal root ganglia (DRG) in the AuPPEG and AuCoOPPEG groups; whereas the number of apoptotic Schwann cells (cleaved caspase 3-labelled) was significantly lower. Furthermore, numbers of activated and apoptotic Schwann cells in the regenerative matrix correlated with axonal outgrowth, whereas HSP27 expression in the regenerative matrix and in DRGs did not show any correlation with axonal outgrowth. We conclude that gold and cobalt-oxide nanoparticle modified membranes in conduits improve axonal outgrowth and increase the regenerative performance of conduits after nerve reconstructionÖğe Herceptin-conjugated magnetic polystyrene-Agsbox nanoparticles as a theranostic agent for breast cancer(SAGE, 2022) Karahaliloğlu, Zeynep; Kılıçay, Ebru; Hazer, BakiBreast cancer is a malignant tumor, which has derived from cells of the breast. Further, a relatively rapid metastasis, and resistance development against all the conventional drug combinations are major clinical issues in breast cancer patients as well as limitations like toxicity, genetic mutation, and metastasis make difficult the use of conventional therapy methods such as chemotherapy, radiotherapy, and local surgery. Therefore, considering the urgent needs, and high death rate in breast cancer cases, the development of new diagnosis and treatment regimens which diagnosed at the early stage and protected normal tissues required for clinical applications. Recently, the combination of tumor diagnosis and treatment within a single platform is a novel perspective, and magnetic nanoparticles are potential candidate owing to their low toxic effect, biocompatibility, biological degradability, superior magnetic properties, and targeting ability to overcome the problems of conventional diagnosis and therapy techniques. Considering these restrictions and requirements, the goal of this research was to investigate the potential of an innovative theranostic agent, which is soybean oil-based polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox) for treatment and MRI-based diagnosis of cancer. Herein, we designed targeted magnetic PS-Agsbox nanoparticles carrying thymoquinone (TQ) that is known for its anticancer potential against breast cancer, and herceptin (HER), which is to bind to the HER2 receptor protein on the surface of HER2-positive tumor cells, and acts by blocking the effects of it. We have successfully demonstrated selective binding, effective uptake of HER-conjugated magnetic PS-Agsbox nanoparticles into MDA-MB-231 (human breast carcinoma cells, a HER2-underexpressing cell line) and SKBR-3 (human breast cancer cells, a HER2-overexpressing breast cancer cell line) cell lines while no effect against L929 (mouse fibroblast cell line). Moreover, the magnetic resonance (MRI) properties of HER-conjugated magnetic PS-Agsbox nanoparticles were also confirmed.Öğe Newly designed bioanode for glucose/O-2 biofuel cells to generate renewable energy(Wiley, 2019) Korkut, Seyda; Kılıç, Muhammet Samet; Hazer, BakiA copolymer poly(methyl methacrylate-co-vinylferrocene) was synthesized and used for the first time in a biofuel cell design. Bioanaode enzyme glucose oxidase and biocathode enzyme bilirubin oxidase were physically immobilized onto the copolymer-modified electrodes. Characterization studies were conducted by scanning electron microscopy, carbon-13, fourier transform infrared and hydrogen-1 nuclear magnetic resonance, and cyclic voltammograms. The designed biofuel cell was operated with linear sweep voltammetry. The maximum current was at 45 degrees C with 120 mu g of polymer amount. An improved power density of 323 mu W cm(-2) that is higher than other ferrocene-based fuel cells was obtained with 10-mM glucose at 0.4 V with the designed bioanode.Öğe Novel poly(3-hydroxy butyrate) macro RAFT agent. Synthesis and characterization of thermoresponsive block copolymers(2020) Hazer, Baki; Eren, Melike; Senemoğlu, Yetkin; Modjinou, Tina; Renard, Estelle; Langlois, ValérieA novel reversible addition fragmentation transfer (RAFT) agent based on the poly-3-hydroxy butyrate (PHB) with threehydroxyl groups (PHB-R2) and thermoresponsive amphiphilic block copolymers derived from N-isopropyl acryl amide(NIPAM) are described. Hydroxylated PHB is obtained by the reaction between PHB and diethanol amine (DEA) to preparehydroxylated PHB (PHB-DEA). It is then reacted with a RAFT agent, 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid(DDMAT). Hydroxyl ends of the hydroxylated PHB are capped with carboxylic acid end of the trithiocarbonate. The blockcopolymers obtained by the polymerization of NIPAM initiated by PHB-R2 were characterized by1H NMR and physicochem-ical techniques. PHB content in the obtained block copolymers is varying between 14 and 45 wt%. The thermo-responsive PHB-PNIPAM block copolymers show the lower critical solution temperature (LCST) 28 and 30 °C while LCSTof the pure PNIPAMis 32 °C.Öğe Novel porous carbon microtubes and microspheres produced from poly(CL-b-VbC) triarm block copolymer as high performance adsorbent for dye adsorption and separation(Elseiver, 2020) Toprak, Atakan; Hazer, BakiDandelion-like and microtube-containing novel porous carbons were synthetized from brush type poly (? caprolactone-b-4-vinyl benzyl chloride) (poly(CL-b-VbC)) triarm block copolymer with KOH (PCLVbK) and ZnCl2 (PCLVbZn) through optimized chemical activation at low temperature. These porous carbons were used for the adsorption and separation of cationic Malachite green (MG) and anionic Congo red (CR) and Methyl or ange (MO) dyes. The synthetized porous carbons were characterized by SEM, N2 adsorption-desorption iso therms, FTIR, Raman and XRD. PCLVbK and Zn porous carbons were quite effective in cationic (MG) dye adsorption from aqueous solution thanks to different functional groups, surface areas and pore volumes. The MG adsorption capacities of PCLVbZn and PCLVbK were found to be 1684 mg/g and 869.5 mg/g, and these results are considerably higher than the other adsorbents studied in the literature. Also, it was determined that while PCLVbZn could adsorb both cationic and anionic dyes, PCLVbK could only perform the adsorption of cationic dyes. The kinetic studies conducted with MG showed that both PCLVbK and Zn porous carbons fitted better with the pseudo-second-order model. At the end of the adsorption equilibrium studies, it was observed that PCLVbZn fitted with both the Langmuir and Freundlich adsorption models while PCLVbK fitted better with the Langmuir model. In conclusion, it was observed that PCLVbK could perform high and fast adsorption and separa tion owing to its oxygen functional groups, while PCLVbZn turned out to be effective in the adsorption of both anionic and cationic dyes thanks to its large surface area (1006 m2 /g) and empty microtubes. Based on these re sults, it can be argued that PCLVbK and Zn porous carbons are promising adsorbents for both high adsorption and effective separation from aqueous solutioÖğe Physical, biological and chemical characterisation of wood treated with silver nanoparticles(Springer, 2019) Can, Ahmet; Palanti, Sabrina; Sivrikaya, Huseyin; Stefani, Federico; Hazer, BakiNowadays, environmentally friendly processes are of great interest and are considerably needed due to the environmental pollution seems to be a problem worldwide. For this reason, in this study, silver nanoparticles were synthesized using environmentally-friendly methods and their effectiveness as wood preservatives was investigated. Scots pine (Pinus sylvestris L.) samples were impregnated with an autoxidized soybean oil polymer containing Ag nanoparticles (Agsbox). Samples characterised by Fourier transform infrared spectroscopy (FTIR) were tested against brown rot (Coniophora puteana) and wood-destroying insects (Hylotrupes bajulus). In addition, decay tests were applied to mini-block samples leached according to the EN 84 standard. Results demonstrated that Agsbox increased decay resistance in the unleached samples. However, low efficacy was exhibited against newborn H. bajulus larvae. As a results of FTIR measurement, impregnated with the nanocomposites showed significant changes at the 2910cm(-1) (C-H) and 1712cm(-1) (C=O) peaks.Öğe PLinaS-g-PEG Coated Magnetic Nanoparticles as a Contrast Agent for Hepatocellular Carcinoma Diagnosis(Taylor Francis, 2020) Hazer, Baki; Karahaliloğlu, Zeynep; Kılıçay, EbruAmong many different types of fabricated nanoparticles, magnetic iron oxide nanoparticles (MNPs) have unique physical and chemical properties and have been widely used due to theirs enhanced permeability and retention effect for biomedical applications. The incorporated theranostic MNPs into biopolymer coatings are currently particular interest to investigators in the fields of nanobiomedicine because of efficiently delivering of various drugs, genes and providing imaging properties. Hepatocellular carcinoma (HCC) is the most prevalent reason of cancer-related deaths, makes it one of the worst malignant tumors in the world. Because, there is a lack of effective treatment methods for HCC, aforementioned magnetic carrier technology with recent innovations could be a promising tool in HCC diagnosis and treatment. Therefore, this study proposes a novel fatty-acid-based polymeric magnetic nanoprobe for diagnosis of hepatocellular tumors using polyethylene glycol (PEG)-terminated polystyrene (PS)-linoleic copolymer coated magnetic iron oxide nanoparticles. MNPs were synthesized by a co-precipitation method and were subsequently coated with a copolymer containing PEG group as termini. Fifty-nanometersized MNPs were incorporated into the core of PLinaS-g-PEG nanoparticles. The morphology and size distribution of the bare and magnetic PLinaS-g-PEG were determined by transmission electron microscopy (TEM), and dynamic light scattering (DLS), respectively. MTT and flow cytometry assays showed that PLinaSg- PEG MNPs demonstrated ultrasentive apoptotic behavior against cancerous cell line, i.e. HepG2 in the culture plate when the fatty acid-containing polymer coated MNPs showed no adverse effect on L929 cell growth. The localization, and accumulation in hepatocytes of PLinaS-g-PEG MNPs without specific targeting ligand was confirmed by fluorescence and confocal microscopy. Therefore, PLinaS-g-PEG MNPs may be potentially used as a unique candidate for diagnosis of hepatocellular carcinomas.
