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  • Küçük Resim
    Öğe
    DİKKAT EKSİKLİĞİ HİPERAKTİVİTE BOZUKLUĞUNDA BESLENME VE DİYET TAKVİYELERİ
    (22024) Ozer, Nurhayat Tugra; Gunes-Sahin, Gulsah
    Dikkat eksikliği hiperaktivite bozukluğu (DEHB), çocukluk çağından yetişkinliğe kadar devam edebilen dikkatsizlik, hiperaktivite ve dürtüsellikle karakterize yaygın bir klinik durumdur (Faraone, 2015; Faraone, 2024). Sendromun bilinen ilk tanımı MÖ 493’te Hipokrat’a aittir, Alman ve İskoç hekimler tarafından tıp ders kitaplarındaki ilk tanımı ise 18.yüzyılın sonuna dayanmaktadır (Faraone, 2015).
  • Küçük Resim
    Öğe
    SAKLI TEHDİT: ENDOKRİN BOZUCULAR
    (2024) Gunes-Sahin, Gulsah; Ozer, Nurhayat Tugra
    Endokrin bozucu kimyasal maddeler (EBK’ler), endokrin sistemin fonksiyonlarını bozan ve insan sağlığı üzerinde ciddi olumsuz etkilere yol açabilen dış kaynaklı maddelerdir. EBK’ler endüstriyel faaliyetler sonucu çevreye yayılmakta ve geniş bir maruziyet alanına sahip olmaktadır. Bu kimyasallar, hormon sistemine müdahale ederek çeşitli organ ve sistemler üzerinde zararlı etkilere neden olurlar. Son yıllarda EBK’lerin özellikle kanser ve üreme sistemi bozuklukları gibi ciddi sağlık sorunlarına neden olduğu, çeşitli hayvan çalışmalarıyla ortaya konulmuştur. Endokrin bozucu kimyasallar, çevrede yaygın olarak bulunmaları ve biyolojik sistemler üzerindeki etkileri nedeniyle önemli bir halk sağlığı sorunu haline gelmiştir (Nohynek ve ark., 2013).
  • Küçük Resim
    Öğe
    The Incidence and Risk Factors of Refeeding Syndromelike Hypophosphatemia in Inflammatory Bowel Disease: A Preliminary Study
    (2024) Ozer, Nurhayat Tugra; Can-Sezgin, Gulten; Sahin-Ergul, Serap; Gunes-Sahin, Gulsah; Yurci, Mustafa Alper; Guven, Kadri; Gundogan, Kursat
    Background & Aims: Refeeding syndrome (RFS) is defined by the presence of acute electrolyte disturbances, including hypophosphatemia. Underlying disease(s), malnutrition and hospitalisation are known risk factors for RFS. It can occur in patients with inflammatory bowel disease (IBD). We aimed to determine the frequency of hypophosphatemia and the relationship between hypophosphatemia, disease severity and nutritional status in hospitalized patients with IBD. Methods: This study was performed prospectively in hospitalized adult patients for the treatment of IBD in a tertiary-care hospital. Disease severity was assessed using Truelove and Witts score for ulcerative colitis (UC) and Crohn‘s Disease Activity Index for Crohn’s disease (CD). Nutritional status was determined using Subjective Global Assessment (SGA). Serum phosphate concentration was recorded for first 7 days after hospitalization, and less than 0.65 mmol/l was defined as hypophosphatemia. Results: Fifty participants (33 with UC and 17 with CD) were included in the study. The mean age of the study sample was 43.4±14.9 years, of which 64% were male. A total of 8.8% of patients with UC and 37.5% of patients with CD had severe (>moderate) disease upon study admission. Seventeen patients (34%) were malnourished. During the 7 study days, 23 participants (46%) had at least one episode of hypophosphatemia. Serum phosphate concentration was significantly and moderately correlated with serum potassium concentration in both the patients and the hypophosphatemia group on study day 3 (p<0.05). Multivariate logistic regression analysis showed that the presence of malnutrition [odds ratio (OR) = 3.64, 95% confidence interval (CI): 1.52-5.58, p=0.008), the administration of parenteral nutrition (OR=2.91, 95%Cl: 1.37-4.63, p=0.015), and severe IBD (OR=1.74, 95%CI: 1.03-3.42, p=0.020) were associated with hypophosphatemia. Conclusions: Approximately half of the participants exhibited at least one instance of hypophosphatemia during the study period. Hypophosphatemia was found to be associated with malnutrition, parenteral nutrition, and severe disease in patients with IBD requiring hospitalization.