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    12-17 Yaş Aralığındaki Spor Yapan ve Yapmayan Ergenler İle Bağımlılık Öyküsü Bulunan Ergenlerin Beyin Dokularının Hacimsel Değişimler Açısından İncelenmesi
    (2023) Temircan, Zekeriya; Artar, Müge; Dönmez, Halil; Ökçesiz, İzzet; Yiğit, Hüseyin
    Bu çalışmada; 12-17 yaş aralığında spor yapan, yapmayan ve madde bağımlılığı öyküsü bulunan ergenlerin beyin dokularında meydana gelen hacimsel değişimlerin beyin MR görüntüleri ile karşılaştırılarak saptanması amaçlanmıştır. Katılımcılardan elde edilen beyin MR görüntüleriyle, ergenlerin spor yapıp-yapmama durumunda ve madde bağımlılığı durumunda beyin makro ve mikro yapılarında meydana gelen hacimsel değişimler incelenmiştir. Çalışmada; 10 kişi düzenli spor yapanlardan, 10 kişi normal bireylerden ve 10 kişi en az bir yıl kadar metamfetamin/amfetamin bağımlılık öyküsü bulunan ergenlerden elde edilen beyin MR görüntüleri, Matlab tabanlı Statistical Parametric Mapping 12 ve web tabanlı volBrain yazılımları ile ayrı ayrı incelenmiştir. Böylece her bireyin beynindeki loblarda ve diğer sahalarda (gri ve beyaz cevher, cerebrospinal sıvı hacmi, cerebellum ve alt yapıları, subcortical bölgeler = nuc. accumbens, amygdala, nucleus caudatus vs, cerebral ve cerebellar cortex cerebri kalınlıkları ile alt yapıları gibi) meydana gelen hacimsel değişiklikler karşılaştırılmıştır. Sonuç olarak metamfetamin kullanan ergenlerin özellikle subkortikal beyin hacim oranlarında spor yapanlara ve yapmayanlara göre artış gözlemlenmiştir. Her ne kadar beynin kortikal bölgelerinde artış gözlemlenmemiş olsa da metamfetamin kullanan bireylerin subkortikal bölgelerinde ki hacimsel değişim bu bireylerin sosyal beceri, sosyal biliş, hafıza, öğrenme ve hatırlama gibi fonksiyonlarında olumsuz sonuçlara yol açacağı belirtilmektedir. Spor yapan ve yapmayan bireylerin beyin MR sonuçlarında herhangibir anormalliğe rastlanılmaması beklenen bir durum olsa da bu bulguları somut bir şekilde bu çalışmaya ile ortaya koymak alan yazına yeni bulgular eklenmesine yardımcı olmuştur.
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    Examining the Relationship between Depression, Anxiety and Stress in Kidney Cancer Patients
    (2022) Demirtaş, Türev; Temircan, Zekeriya
    Cancer of the kidney is one of the 10 most common cancers found globally. Overall, it is the fourth most common cancer in men and the eighth most common cancer in women. Many kidney cancer patients experience psychologic problems and reactions. The present study examined relationship between anxiety, depression, and perceived stress symptoms in kidney cancer patients. Cross-sectional data were obtained from the patients diagnosed with kidney cancer. All participants completed sociodemographic form, Hospital Anxiety and Depression form, and Perceived Stress Scale. Statistical analysis was exercised using the Student’s t-test, Chi-squared test (?2), Fischer’s exact test, ANOVA, Mann–Whitney U test, and Kruskal–Wallis one-way variance analysis. A total of 250 patients participated in the study. The mean age was 57.4 years (SD 6.4, range = 25–76 years). The majority of patients were males (73%) and married (218). Anxiety symptoms were determined in 91.2% patients, depression symptoms in 87.2% patients, and perceived stress symptoms in 93.6% patients. The mean scores of Hospital Depression and Anxiety Scale (HADS)-Anxiety, HADS-Depression, and HADS-Perceived Stress were significantly different between age (P < 0.05), gender (P < 0.05), and income groups (P < 0.001). Kidney cancer patients showed poorer psychologic health. The overall levels of anxiety, depression, and perceived stress symptoms were higher among the studied kidney cancer patients. Findings of the current study could improve both psychologic well-being of patients and health-related quality of life.
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    Health-related quality of life, depression, anxiety and sexual dysfunction in patients with testicular cancer
    (2021) Demirtaş, Türev; Temircan, Zekeriya
    Background and objective: Testicular cancer is one of the most common cancer types among young men. Although there is high percentage of cure rates for the patients, there is a lack of knowledge regarding health-related quality of life, psychological problems and sexual dysfunction. The aim of this study was to examine health-related quality of life, anxiety, depression and sexual dysfunction in patients with testicular cancer. Methods: Data were collected from 160 patients diagnosed with testicular cancer at age 20–60 years. The survey method was used to collect information. Results: The results showed that the mean scores of SF-12v2 physical component (p = 0.02), HADSanxiety (p < 0.011) and HADS-depression (p = 0.01) were significantly different between marital status groups. The mean scores of IIEF-5 were significantly different between income groups (p = 0.01) and employment status (p = 0.02). Participants who earned low income, had primary or lower education, and were not employed reported significantly poorer erectile function than their higher earning, higher educated and employed counterparts. Also, HADS anxiety and HADS depression scores were found to be moderate and positively correlated with IIEF-5 (p < 0.01). However, SF-12v2 physical component summary and mental component summary scores were negatively correlated with IIEF-5 (p < 0.01). Conclusion: The current study findings provided knowledge on health-related quality of life, anxiety, depression and sexual dysfunction in patients with testicular cancer. Health-related quality of life, psychological mental health and sexual life were poorer among the participants.
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    The Effects of Active Methamphetamine Use Disorder and Regular Sports Activities on Brain Volume in Adolescents
    (Journal of Clinical Medicine, 2025) Yiğit, Hüseyin; Güler, Hatice; Temircan, Zekeriya; Gökoğlu, Abdulkerim; Ökçesiz, İzzet; Artar, Müge; Dönmez, Halil; Unur, Erdoğan; Yılmaz, Halil
    Objectives: Methamphetamine (MA) abuse during adolescence can have a significant impact on brain development. On the other hand, regular exercise is known to promote brain health and may have neuroprotective effects. The purpose of this study is to compare brain volumes in three different adolescent groups: those with active methamphetamine use disorder (MUD), adolescent athletes who regularly exercise, and healthy control adolescents. Methods: This MRI study involved three groups of adolescents: 10 with active MUD (9 males, 1 female), nine licensed runner adolescents (three males, six females), and 10 healthy adolescents (5 males, 5 females). Brain volumes were analyzed using T1-weighted images from a 3.0 Tesla MRI scanner, and then segmented automatically with vol2Brain. Statistical analyses included ANCOVA with sex as a covariate and LSD post hoc tests performed using SPSS Statistics 23. Results: Adolescents with MUD showed a 10% increase in total white matter volume compared to the athlete group. Conversely, cortical gray matter volume was reduced by 4% compared to the healthy control group and by 7% compared to the athlete group. The frontal and insular cortices in the MUD group had significantly diminished volumes compared to the athlete group. Overall, individuals with MUD had decreased gray matter volumes and increased white matter volumes in their brains. The brain volumetric differences between the MUD group and the athlete group were statistically significant. Conclusions: The brains of those with MUD displayed a reduction in gray matter volume and an increase in white matter volume, indicating damage from MA on the developing adolescent brain. The volumetric disparities between the MUD and athlete groups were found to be significantly different, suggesting a possible neuroprotective factor of exercise. Further studies are required to explore the potential of exercise-based interventions in alleviating the harmful effects of MA abuse.