Beslenme ve Diyetetik - Makale Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/20.500.12695/302

Listeleniyor 1 - 20 / 28

Seasonal distribution of Ephemeroptera (Insecta) of the Kızılırmak Basin with evaluation of the water quality based on physicochemical parameters and benthic metrics
(Springer, 2022) Öztürk, Selda; Dügel, Muzaffer; Çiçek, Erdoğan; Koyuncuoğlu, Serdar; 0000-0002-5639-7962; Kapadokya Üniversitesi, Sağlık Bilimleri Yüksekokulu, Beslenme ve Diyetetik Bölümü; Öztürk, Selda
This study was carried out to determine the seasonal distribution of the Ephemeroptera of the Kızılırmak Basin and to evaluate the relations of the identified taxa with the physicochemical variables in their distribution areas, to reveal the ecological water quality through both these parameters and the benthic metrics developed for the Kızılırmak basin. Field studies were carried out in 13 different localities in spring, summer and autumn periods in 2018. A total of 990 individuals were examined and 27 species belonging to seven families were identified. Species diversity according to Shannon-Wiener (H) values was highest at station 8 (1.52) and lowest at station 7 (0.23) in the spring period, highest at station 3 (1.49) lowest at station 7 (0.23) in the summer period, and highest at the 2nd (1.44) and lowest at the 4th (0.14) station in the autumn period. According to the calculated average H values of the stations, the stations 4, 6, 7, 10 and 12 were determined in the polluted water class, while the other stations were determined in the moderate polluted water class. According to cluster analysis; the highest similarities were seen between the station 1 and the stations 2 and 9 (71%). According to the ANOSIM result, in which the differences between the seasonal distributions of the species were evaluated, there was a significant difference between the spring period and the summer and autumn periods. According to the result of MANOVA, which was applied to understand the differences between environmental variables and seasonal groups, there was a significant difference between spring and summer seasons in terms of temperature variable, while dissolved oxygen variable was significantly differed among all season groups. The water quality of the stations was evaluated together with the biotic index based on physico-chemical variables and benthic metrics, and the stations with reference characteristics were determined. Accordingly, in terms of both physicochemical parameter measurements and index values calculated on biological data, it was determined that the stations are mostly in reference feature (high, good and moderate quality water class) away from pollution pressure.
Gıda Kaybı ve İsrafında Güncel Durum ve Azaltma Stratejileri
(2025) Kip, Merve; Serçe Sarıtaş, Mümine Kübra; Kaldırım, Beyza; Aytekin Şahin, Gizem; 0000-0002-8814-8506; Kapadokya Üniversitesi, Sağlık Bilimleri Yüksekokulu, Beslenme ve Diyetetik Bölümü; Serçe Sarıtaş, Mümine Kübra
Küresel nüfusun 2050 yılına kadar 10 milyarı aşması öngörülmektedir. Bu hızlı büyüme, özellikle gıda kaybı ve israfının artmasıyla birlikte, yeterli gıdanın sağlanması konusundaki endişeleri artırmıştır. Birleşmiş Milletler Gıda ve Tarım Örgütü (Food and Agriculture Organization of the United Nations, FAO), 2022 yılında dünya genelinde toplam 1,05 milyar ton gıda israf edildiğini ve bunun kişi başı 132 kilograma denk geldiğini belirtmiştir. Kırsal bölgeler başta olmak üzere 2,4 milyar insanın yeterli, güvenli ve besleyici gıdaya erişimi olmadığı belirtilmektedir. Gıda kaybı ve israfı, şehirleşme, küreselleşme ve değişen tüketim alışkanlıkları gibi çeşitli faktörler nedeniyle gıda tedarik zincirinin her aşamasında meydana gelmektedir. Gıda kaybını ve israfını azaltmak, gıda güvencesizliğini önemli ölçüde azaltabilir ve çevresel sürdürülebilirliği iyileştirebilir. Türkiye’de ve dünyada gıda kaybını ve israfını önlememeye yönelik yürütülen uygulamalar arasında sürdürülebilir gıda sistemleri stratejileri, teknolojik yenilikler ve politika faaliyetleri yer almaktadır. Gıda kaybı ve israfının azaltılması, gıda güvenliğini artırmaya, çevresel etkileri azaltmaya ve küresel sürdürülebilir kalkınma hedeflerine ulaşmaya katkı sağlamaktadır. Bu derlemenin amacı dünyada ve Türkiye'de gıda israfı ve kaybının durumunu ve olası önleme stratejilerini özetlemektir.
The relationship of the dietary inflammatory index, glycemic load and glycemic index on sleep quality and anthropometric measurements in college students
(Emerald, 2025) Küçükkatırcı Baykan, Hürmet; Öner, Neslihan; Akşehirli Seyfeli, Mevlüde Yasemin; Çiçek, Betül
Purpose – This study aims to determine the relationship between dietary inflammatory index (DII), healthy eating index (HEI), glycemic index and load (GI/GL) with sleep quality and anthropometric measurements in college students. Design/methodology/approach – This was a cross-sectional study. With a type I error of 0.05, a type II error of 0.20, and a minimum power of 90%, the required sample size was calculated to be at least 112 students. However, considering that there might be missing data and that the study was being conducted to increase the power of the study, 500 students were recruited for the study. A total of 500 students (124 males, 376 females) aged 18–25 years were recruited for the study. The students’ socio-demographic characteristics, anthropometric measurements (body weight, height, neck, waist and hip circumferences), sleep quality and three-day food consumption records were examined. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI). Findings – The total PSQI score median value was 7 (1–17). In total, 65.4% of the students had poor, and 34.6% had good sleep quality. The minimum DII score was ?9.67, and the maximum DII score was 10.41. The mean of DII was 2.51 ± 3.26. DII scores were evaluated by dividing them into quartiles. In DII Quartile 1, representing the anti-inflammatory diet, values were between ?9.67 and +0.18; in DII Quartile 2, values were between +0.23 and +2.47; in DII Quartile 3, values were between +2.55 and +4.50; DII Quartile 4, representing the proinflammatory diet, values were between +4.52 and +10.41. Waist circumference and waist-to-hip ratio significantly differed between quartiles (Q1 < Q2 < Q3 < Q4 and Q2 < Q3 < Q4, respectively) (p < 0.05). GL and HEI-2015 scores significantly differed between quartiles (Q1 < Q2 < Q3 < Q4 and Q1 > Q3 > Q4, respectively) (p < 0.05). There was a significant positive correlation between DII and GL(r = +0.189, p < 0.001) and a significant negative correlation between DII and HEI-2015 (r = ?0.213, p < 0.001). Originality/value – The study’s original aspect is that food consumption records were obtained instantaneously from the participants via social media, and the relationship of multiple indices (DII, HEI-2015, GI, GL) with each other and with sleep quality and anthropometric measurements were evaluated.
A new communication model between clients/patients and dietitians: Telenutrition, evaluation of the perspectives of clients/patients and dietitians
(Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 2025) Küçükkatırcı Baykan, Hürmet; Öner, Neslihan
Purpose: The aim of this cross-sectional study was to determine the status, advantages, and disadvantages of telenutrition from the perspectives of clients/patients and dietitians. Methods: A total of 100 clients/patients and 100 dietitians were recruited to this cross-sectional study. To assess the status as well as the advantages and disadvantages of telenutrition, a set of inquiries, based on the literature review, were posed to both clients/patients and dietitians. Results: Both dietitians (%92) and clients/patients (%61) were found to use telenutrition mainly for weight loss diets. It was found that clients/patients who had time constraints due to their busy lifestyle (63%) and whose dietitian was in another city (36%) preferred telenutrition more frequently. Clients/patients (51%) were more concerned than dietitians (32%) that anthropometric measurements were not taken by the expert (p<0.05). 44% of clients/ patients stated that they frequently change their appointments due to the time-flexible system. Conclusion: Telenutrition has become a necessity today due to the time constraints that many people complain about due to their busy lifestyles, difficulties in traveling to and from hospital/clinic, especially in the elderly age group, pandemics, or natural disasters. In this direction, the steps to be taken to improve telenutrition will increase the quality of telemedicine services. When making relevant improvements, the opinions of the clients/patients group receiving this service and the dietitians providing this service should be consulted and the participation of clients/patients in the formation of health policies should be supported.
Comparison of SARC?F and Ishii score in screening for sarcopenia in older adults with type 2 diabetes mellitus: which screening tool should we use?
(Springer, 2024) Akgul, Yavuz Sultan Selim; Eren Cengiz, Burcu; Gunes-Sahin, Gulsah; Kocaslan, Derya; Deveci, Neziha Ozlem; Akin, Sibel
Background Sarcopenia is common in older adults, and type 2 diabetes mellitus (DM), highly prevalent in older adults, is a risk factor for sarcopenia. Early detection of sarcopenia is vital for the implementation of preventive and therapeutic measures. Objective We aimed to compare the SARC-F questionnaire and Ishii score screening methods for sarcopenia in patients with type 2 DM. Methods This cross-sectional study was conducted on 462 older adults with diabetes aged ? 60. Muscle mass and strength were assessed using the BIA device and handgrip dynamometer. Sarcopenia was defined in line with the European Sarcopenia Working Group 2 (EWGSOP2). The SARC-F questionnaire and Ishii score in screening for sarcopenia were compared. Results The median age was 72 (67–76) for males and 68 (65–74) for females. The prevalence of sarcopenia based on the Ishii score, SARC-F, and EWGSOP2 was 28.4%, 40.9%, and 61.9%, respectively. The sensitivities of Ishii score and SARCF in screening for sarcopenia were 84% and 47%, respectively. The Ishii score and SARCF specificities were 67% and 69%, respectively. PPV and NPV for the Ishii score were 79% and 45%, respectively. The PPV and NPV for the SARC-F were 71% and 55%, respectively. The AUC values of the Ishii score and SARC-F were 0.790 and 0.598, respectively. Conclusion The Ishii score can be used in daily practice to screen for sarcopenia in older adults with type 2 DM.
The Incidence and Risk Factors of Refeeding Syndromelike Hypophosphatemia in Inflammatory Bowel Disease: A Preliminary Study
(2024) Ozer, Nurhayat Tugra; Can-Sezgin, Gulten; Sahin-Ergul, Serap; Gunes-Sahin, Gulsah; Yurci, Mustafa Alper; Guven, Kadri; Gundogan, Kursat
Background & Aims: Refeeding syndrome (RFS) is defined by the presence of acute electrolyte disturbances, including hypophosphatemia. Underlying disease(s), malnutrition and hospitalisation are known risk factors for RFS. It can occur in patients with inflammatory bowel disease (IBD). We aimed to determine the frequency of hypophosphatemia and the relationship between hypophosphatemia, disease severity and nutritional status in hospitalized patients with IBD. Methods: This study was performed prospectively in hospitalized adult patients for the treatment of IBD in a tertiary-care hospital. Disease severity was assessed using Truelove and Witts score for ulcerative colitis (UC) and Crohn‘s Disease Activity Index for Crohn’s disease (CD). Nutritional status was determined using Subjective Global Assessment (SGA). Serum phosphate concentration was recorded for first 7 days after hospitalization, and less than 0.65 mmol/l was defined as hypophosphatemia. Results: Fifty participants (33 with UC and 17 with CD) were included in the study. The mean age of the study sample was 43.4±14.9 years, of which 64% were male. A total of 8.8% of patients with UC and 37.5% of patients with CD had severe (>moderate) disease upon study admission. Seventeen patients (34%) were malnourished. During the 7 study days, 23 participants (46%) had at least one episode of hypophosphatemia. Serum phosphate concentration was significantly and moderately correlated with serum potassium concentration in both the patients and the hypophosphatemia group on study day 3 (p<0.05). Multivariate logistic regression analysis showed that the presence of malnutrition [odds ratio (OR) = 3.64, 95% confidence interval (CI): 1.52-5.58, p=0.008), the administration of parenteral nutrition (OR=2.91, 95%Cl: 1.37-4.63, p=0.015), and severe IBD (OR=1.74, 95%CI: 1.03-3.42, p=0.020) were associated with hypophosphatemia. Conclusions: Approximately half of the participants exhibited at least one instance of hypophosphatemia during the study period. Hypophosphatemia was found to be associated with malnutrition, parenteral nutrition, and severe disease in patients with IBD requiring hospitalization.
Determination of the Amount of Food Waste in the University Refectory and the Effect of Improvements Made to Reduce Food Waste
(2025) Demir Özer, Ezgi; Küçükkatırcı Baykan, Hürmet; Esen, Mustafa Kadir; Canarslan, Büşra; Boyacı, Dorukan; Şenol, Vesile
Determining the amount of food waste is crucial for identifying specific areas needing improvement and for measuring the effectiveness of implemented changes. This study aimed to assess food waste in university cafeterias before and after implementing menu improvements and nutritional awareness initiatives. Data collection included food waste measurements, nutrition knowledge seminars, and surveys conducted from December 2020 to August 2021. Menu improvements involved standardizing recipes and enhancing the texture, color, and flavor of meals. Educational initiatives, such as seminars, posters, and brochures, were used to raise awareness about food waste. Overall, food waste decreased significantly after menu changes, particularly in soups, main courses, and second courses (P < 0.05), with the exception of salads and desserts. There were no significant differences in participant characteristics before and after the improvements (P > 0.05). Satisfaction with menu quality and meal service increased significantly (P < 0.001), and participants’ awareness of food waste improved (P < 0.05). The findings indicate that menu improvements and increased nutritional awareness can effectively reduce food waste, thereby mitigating negative environmental and economic impacts.
Investigating the potential infestation region of Redbelly Tilapia (Coptodon zillii, Gervais 1848) in Iraq: Impacts of climate change on distribution
(2024) Öztürk, Selda; Abdualmajeed, Othman Mustafa; Jawad, Hasan S.A.; Suheal, Nuha Imad
The encroachment of invasive species poses a significant threat to native ecosystems, especially in regions vulnerable to the impacts of climate change. This paper aims to examine the potential infestation region of Redbelly Tilapia (Coptodon zillii), an introduced fish species, in Iraq, should the species escape aquacultural facilities. Utilizing a Maxent model, our analysis identifies northern Iraq as the optimal habitat for C. zillii proliferation. Leveraging ecological modeling techniques and climate projections, this research emphasizes the need for proactive measures to prevent the establishment of C. zillii in these northern regions. Specifically, caution is advised against undertaking aquaculture activities in these areas to mitigate the risk of accidental escape and subsequent ecological disruption. By delineating areas of high susceptibility, this study provides actionable insights for conservation efforts and informs policy decisions aimed at preserving the integrity of native ecosystems in the face of environmental change.
Üniversite Öğrencilerinde Gece Yeme Sendromu, Uyku Kalitesi ve Kronotip Arasındaki İlişkinin Değerlendirilmesi
(İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2024) Küçükkatırcı Baykan, Hürmet; Saban, Gaye; Geçgel, Seda
Amaç: Bu çalışma; üniversite öğrencilerinde gece yeme sendromu, uyku kalitesi ve kronotip arasındaki ilişkiyi değerlendirmek amacıyla gerçekleştirilmiştir. Yöntem: Kesitsel tipte planlanan çalışma, 2022 yılı Nisan ile Haziran ayları arasında Kapadokya Üniversitesinde öğrenim gören ve çalışmaya katılmayı gönüllü olarak kabul eden 570 (429 kız, 141 erkek) öğrenci ile yürütülmüştür. Çalışmada öğrencilerin sosyodemografik özellikleri, antropometrik ölçümleri, uyku kaliteleri, kronotipleri, gece yeme durumları ve besin tüketim sıklıkları incelenmiştir. Uyku kalitesi “Pittsburgh Uyku Kalitesi (PUKİ)”, kronotip “Morningness-Eveningness Questionnaire (MEQ)” ölçeği ile, gece yeme sendromu ise “Gece Yeme Anketi (GYA)” ile değerlendirilmiştir. Bulgular: Çalışmaya katılan öğrencilerin yaş ortalaması 21,20±1,34 yıldır. Öğrencilerin PUKİ puanı ortancası 7 (1-17)’dir. PUKİ sınıflandırmasına göre öğrencilerin %60,5’inin (n=345) uyku kalitesi kötü, %39,5’inin (n=225) uyku kalitesi iyidir. Öğrencilerin MEQ puanı ortancası 53 (20-80)’dir. Kronotip sınıflandırmasına göre katılımcıların %24,9’u (n=142) akşamcıl, %67,2’si (n=383) ara ve %7,9’u (n=45) sabahçıl tiptir. Öğrencilerin GYA’dan aldıkları puan ortancası 27 (12-42)’dir. Katılımcıların %82,8’inde (n=472) gece yeme sendromu bulunurken, %17,2’sinde (n=98) gece yeme sendromu bulunmamaktadır. PUKİ ile MEQ arasında negatif yönde, anlamlı (r=-0,136, p<0,05); PUKİ ile GYA arasında pozitif yönde, anlamlı (r=0,380, p<0,001); GYA ile MEQ arasında negatif yönde, anlamlı ilişki saptanmıştır (r=-0,118, p<0,05). Sonuç: Sonuç olarak, öğrencilerin uyku kaliteleri düştükçe kronotipleri akşamcıl tipe geçmekte akşamcıl kronotipe sahip öğrencilerde ise gece yeme sendromu daha sık görülmektedir. Bu döngü sıklıkla tekrarlanmakta bireysel ve halk sağlığı bazında birçok sağlık riskini de beraberinde getirmektedir. Farkındalık ve bilgilendirme çalışmalarının bu sorunun önüne geçilmesinde önemli bir unsur olduğu düşünülmektedir.
Gut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay
(European Journal of Trauma and Emergency Surgery, 2023) Altuntaş Dönmez, Hamiyet; Şahin Ergül, Serap; Altın Çelik, Pınar; Bulut, Kadir; Eciroğlu, Hamiyet; Üzen, Ramazan; Güneş Şahin, Gülşah; Özer, Nurhayat; Temel, Şahin; Arıkan, Türkmen Bahadır; Esmaoğlu, Aliye; Yüksel, Recep Civan; Sungur, Murat; Gündoğan, Kürşat
Purpose In an efort to better manage critically ill patients hospitalised in the intensive care unit (ICU) after experiencing multiple traumas, the present study aimed to assess whether plasma levels of intestinal epithelial cell barrier proteins, including occludin, claudin-1, junctional adhesion molecule (JAM-1), tricellulin and zonulin, could be used as novel biomarkers. Additional potential markers such as intestinal fatty acid-binding protein (I-FABP), d-lactate, lipopolysaccharide (LPS) and citrulline were also evaluated. We also aimed to determine the possible relationships between the clinical, laboratory, and nutritional status of patients and the measured marker levels. Methods Plasma samples from 29 patients (frst, second, ffth and tenth days in the ICU and on days 7, 30 and 60 after hospital discharge) and 23 controls were subjected to commercial enzyme-linked immunosorbent assay (ELISA) testing. Results On frst day (admission) and on the second day, plasma I-FABP, d-lactate, citrulline, occludin, claudin-1, tricellulin and zonulin levels were high in trauma patients and positively correlated with lactate, C-reactive protein (CRP), number of days of ICU hospitalisation, Acute Physiology and Chronic Health Evaluation II (APACHE II) score and daily Sequential Organ Failure Assessment (SOFA) scores (P<0.05–P<0.01). Conclusion The results of the present study showed that occludin, claudin-1, tricellulin and zonulin proteins, as well as I-FABP, d-lactate and citrulline, may be used as promising biomarkers for the evaluation of disease severity in critically ill trauma patients, despite the complexity of the analysis of various barrier markers. However, our results should be supported by future studies.
Anaokulu Menülerinin İyileştirilmesi ve Yemek İsrafının Azaltılması: Kapadokya Üniversitesi Çocuk Gelişimi Uygulama Araştırma Merkezi Örneği
(Türkiye Diyetisyenler Derneği, 2023) Küçükkatırcı Baykan, Hürmet; Yaşar, Şükran; Kütahneci, Elif; Yalap, Rukiye; Şenol, Vesile
Amaç: Deneysel ve karşılaştırmalı olarak yürütülen bu araştırma, bir anaokulunda sunulan yemekleri, çocukların tüketimine uygun hâle getirerek yemek israfını azaltmak amacıyla gerçekleştirilmiştir. Bireyler ve Yöntem: Kapadokya Üniversitesi Çocuk Gelişimi Uygulama ve Araştırma Merkezine bağlı kreşte öğle yemeği hizmeti alan çocukların tamamı çalışmaya dâhil edilmiştir. Çalışma, gözlem periyodu ve yemek örneği iyileştirme aşaması olmak üzere iki aşamalı planlanmıştır. Birinci aşamada artık miktarı en yüksek olan yemek örnekleri ve bu yemeklerin “Artık Miktar Yüzdesi” belirlenmiştir. Çalışmanın ikinci aşamasında artık miktarı yüzdesi yüksek olan yemeklerde grubun özellik ve tercihlerine göre iyileştirmeler yapılmış ve çocuklara “İyileştirilmiş Yemek Örnekleri” sunulmuştur.Bulgular: Çalışma 15 kız, 35 erkek öğrenci olmak üzere toplam 50 çocuk ile gerçekleştrilmiştir. Çocukların yaş ortalaması 50.09±11.75 ay, boy uzunluğu ortalaması 102.09 ± 7.32 cm, vücut ağırlığı ortancası ise 16.60 (14.67-18.42) kilogramdır. Çocukların yaşa göre beden kütle indeksi Z skoru 0.46, persentil değeri 67.7’dir. Çalışma kapsamına alınan sekiz kap yemek örneğinin dördünde (patates oturtma - ıspanak yemeği - barbunya yemeği (sıcak) - çiftlik kebabı) artık miktar yüzdesi istatistiksel açıdan anlamlı olarak azalmıştır (p<0.05). Sonuç: Çalışmanın sonucunda, ilgili grubun özellik ve tercihlerine göre düzenlenen yemek örneklerinin yemek israfını önlemeye yardımcı olduğu gözlenmiştir. Bu sonuç, yemek israfının azaltılması ve katılımcı tercihlerine yönelik besleyici menüler planlanmasında alanında eğitim almış uzman kişilere yetki verilmesinin önemini göstermiştir.
Evaluation of Nursing Home Residents Applying to The Emergency Service
(2022) Kilci, Ali İhsan; Hakkoymaz, Hakan; Gedik, Muhammed Semih; Avşaroğulları, Ömer Levent; Şenol, Vesile; Altuntaş, Mukerrem
Background: Emergency deparment (ED) has an important role at the care of nursing home residents and acts facilitator role at the acute care, admission to the hospital, unexpected injuries and hospitals. Our research is aiming the evaluation of the demographic and clinical features of the nursing home patients applying to ED. Materials and methods: The nursing home residents who are aged 18 and over 18 applying to ED at the date between 15.04.2014-15.05.2015 are included to this respective study. In the study, demographic information of the patients and diagnosis and treatment information in the emergency room were evaluated. Results: 51 (52%) of the patients are male. The average age of them is 73. The most frequent disease observed in their medical history is Alzheimer’s disease. The physical examinations of the patients resulted that they have cachexia and dehydration. The oftenest diagnosises detected are lung disease (23.5%), infection (22.4%) and malnutrition (22.4%). It has been also detected that 45% of them admitted to hospital and 3.1% of them are to die. The rate of intensive care admission is 64% while the service admission rate is 36%. Conclusion: The rate of the admission of the nursing home residents to ER and especially to intensive care units is quite high. To ameliorate this condition, training and supervision of the nursing home workers should be made more carefully and often. Since we do not have sociodemographic and clinical data about the nursing home residents applying to ED, more study must be made about this area.
Changing perceptions of general health in the Kayseri Province, Turkey in 2004 and 2017: A population-based study
(frontiers, 2023) Şenol, Vesile; Elmalı, Ferhan; Çetinkaya, Fevziye; Naçar, Melis
Aim: Self-rated health (SRH) and health-related quality of life (HRQoL) have closely related outcomes inmeasuring general health status in community-based studies. The aimof this study is to determine changes in the self-perceived overall health of people and a?????ected factors by comparing the findings of two studies conducted in the same research area. Methods: Both studies were conducted using the same measurement tools in households determined by random sampling techniques in the same research areas. The first and second studies were conducted with 1,304 and 1,533 people residing in 501 and 801 households in 2004 and 2017, respectively. The demographic data form, the Nottingham Health Profile (NHP), and a single-item SRH questionnaire were used for data collection. Results: The rate of good SRH increased from 56% to 70% while the average NHP score decreased from 30.87 to 20.34. The predictors of negative health perceptions were the presence of chronic diseases (OR 3.4–2.7-times higher), being female (OR.1.4–1.5 times higher), and the completion of primary education only (OR. 2.7–2.8 times higher) both 2004 and 2017. Living 500–1,000m from the nearest healthcare facility was the main protective variable against poor SRH. Conclusions: Good SRH and HRQoL have increased significantly over time. Chronic diseases, education, and gender are the strongest predictors of poor SRH.
Change in Utilization of Health Services and its Affecting Factors in Kayseri City Center: A Comparative Population-Based Cross-Sectional Study in 2004 and 2017
(Türkiye Klinikleri, 2023) Şenol, Vesile; Elmalı, Ferhan; Çetinkaya, Fevziye; Naçar, Melis; Yalap, Rukiye
Objective: This study aimed to examine the change in health service use and its affecting factors by comparing the findings of 2 studies conducted at different times, with the same data collection tools, in the same health service region. Material and Methods: The first cross-sectional study was conducted in 2004, in urban areas in Kayseri, with 501 households and 1,880 people in Primary Health Centers. The second was carried out in 2017, in 30 Family Health Centers, with 801 households and 2,253 people. The data were collected by the face-to-face interview method using a questionnaire. In statistical analysis, mean±standard deviation, median (Q1-Q3), Mann-Whitney U, Kruskal-Wallis, Pearson ?2, logistic regression analysis were used. The value p<0.05 was accepted as statistically significant. Results: The rate of health service utilization (HSU) increased from 79.6% to 84.8%, the average number of visits to physicians per person increased from 4.9 to 6.9. While the proportion of primary HSU increased to 45.8%, requests for visits to public hospital decreased to 26.4%. Healthcare use was significantly higher in male gender (2.2-2.3 times), 65 years and older (2.8-3.2 times), in people with good income (1.8-1.5 times), and in those with negative health perception (1.8-1.9 times). Conclusion: There has been a significant improvement in HSU parameters, particularly in Primary Health Care Centers services. Male gender, good level income, advanced age (?65), and negative health perception are the main determinants of healthcare use. These results require a better understanding of the factors that make access to the health facilities difficult and the development of strategies that ensure fair use of health services.
Üniversite Hastanesinde Çalışan Hemşirelerde İş Kazaları Ve Mesleki Risk Faktörleri Farkındalığının Değerlendirilmesi
(Paramedik ve Acil Sağlık Hizmetleri Dergisi, 2022) Şenol, Vesile; Sunman, Gözde
Bu çalışmanın amacı bir üniversite hastanesinde çalışan hemşirelerin maruz kaldığı iş kazalarının sıklığı, türleri ve mesleki risk faktörlerine ilişkin farkındalığını belirlemektir. Çalışma grubunu Orta Anadolu’da bir kamu üniversitesi hastanelerinde görev yapan 448 gönüllü hemşire oluşturmuştur. Nicel araştırma deseninde yürütülen çalışmada kolayda örnekleme tekniği kullanılmıştır. Çalışma verileri yüz-yüze görüşme tekniği ile anket uygulanarak toplanmıştır. Yaş ortalaması 31.84±6.27 olan hemşirelerin %90,0’ı kadın, %94,2’si lisans ve üzeri eğitim düzeyine sahiptir. Hemşirelerde iş kazası geçirme sıklığı %47,5, en sık maruz kalınan iş kazası türü (%73,2) kesici-delici alet yaralanmasıdır. Aşırı iş yükü ve çalışma sürelerinin uzunluğu en önemli (%84,2) iş kazası nedenidir. Sağlığı ve güvenliği tehlikeye düşürecek olası işyeri risk faktörleri farkındalığı olan ve eldiven kullanımı, el hijyeni gibi standart bireysel koruyucu tedbirlere uyan hemşirelerde iş kazasına maruziyet oranı anlamlı düzeyde daha düşüktür. Diğer taraftan uyku ve beslenme bozukluğu, Lateks allerjisi, iş doyumsuzluğu ve tükenmişlik yaşayan hemşirelerde iş kazasına maruziyet oranı anlamlı düzeyde daha yüksektir. Kurumsal tedbirler düzeyinde, çalışma saatleri içinde alınan güvenlik önlemleri (%52,2), İSİG denetimleri (%30,4), periyodik sağlık kontrolleri (%14,3), iş kazalarını önlemede ergonomi ilkelerinden yararlanımı (%29,3), risk azaltmaya yönelik kontrol ve çözüm uygulamalarını (%30,6) olumlayan yanıtlar düşük düzeyde kalmıştır. Kurumsal düzeyde koruyucu/önleyici tedbirleri iyileştirecek ve çalışanlarda mesleki risk farkındalığı ve korunma kültürü geliştirecek mesleki iş güvenliği programlarının geliştirilmesi ve uygulanması kaçınılmaz görünmektedir.
Altın Çilek/Yer Kirazı (Physalis Peruviana L.) Meyvesinin Botanik Özellikleri ve Sağlık Üzerine Etkileri
(Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, 2023) Yaşar, Şükran; Kütahneci, Elif; Delimustafaoğlu, Fatma Gül; Erdem Büyükkiraz, Mine
Physalis peruviana, Patlıcangiller (Solanaceae) familyasının Physalis cinsine ait Güney Amerika’nın tropikal bölgelerinde doğal yayılış gösteren egzotik bir türüdür. Sarı-turuncu renkte, hemen hemen yuvarlak, üzümsü ve etli yapıda olan P. peruviana meyveleri çeşitli rakımlara, topraklara ve iklim koşullarına uyum sağlayabilmektedir. Physalis cinsinin ülkemizde doğal olarak yetişen dört türü bulunmaktadır ve halk arasında güveyfeneri olarak bilinen cinsin kültürü yapılmakta olup, ekonomik öneme sahip olduğu bilinmektedir. C vitamini, fosfor potasyum ve fenolik bileşikler açısından zengin olan P. peruviana fonksiyonel bir ürün özelliği göstermektedir. Farmakolojik ve fitokimyasal çalışmalarda antibakteriyel, antikanserojen, antidiyabetik, antioksidan etkileri ortaya konulmuştur. Domatese oldukça yakın tat ve görünüşü olan P. peruviana meyvesinin taze tüketiminin yanı sıra meyve suyu, marmelat, reçel ve tatlılarda, soslarda ve glazelerde kullanımı yaygındır. Hem kendine has lezzeti, hem de sağlık üzerinde birçok etkisi sebebiyle bu meyvenin gelecekte daha fazla yaygınlaşması beklenmektedir. Bu çalışmada P. peruviana bitkisinin botanik ve fonksiyonel özelliklerine değinilerek sağlık üzerindeki potansiyel etkileri değerlendirilmiş ve alternatif kullanım alanları ile ilgili bilgiler derlenmiştir.
Diabetes Mellitusta Metabolik Hafızanın Rolü
(Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 2022) Küçükkatırcı, Hürmet; Caferoğlu, Zeynep; Hatipoğlu, Nihal
Diabetes Mellitus, morbidite ve mortalitenin artmasına neden olan, önemli bir halk sağlığı problemidir. Diyabetin spesifik bulgusu olan hiperglisemi, çeşitli ilaçlar veya ekzojen insülin uygulaması yolu ile klinik olarak kontrol edilmeye çalışılmaktadır fakat gerek tedavi gerekse takipteki gelişmelere rağmen diyabetli birçok hastada vasküler komplikasyon gelişme durumunun önüne hâlen tam anlamı ile geçilememiştir. Çeşitli epidemiyolojik ve geniş kapsamlı çalışmalar, erken ve yoğun hiperglisemi kontrolünün diyabet ile ilişkili komplikasyon riskini azalttığını göstermiştir ve ilgili çalışmaların tamamı, erken glisemik kontrolün gerekliliğini vurgulamaktadır. Erken dönemdeki hiperglisemi kontrolü yakın zamanda “metabolik hafıza” olarak tanımlanmıştır. Mitokondri ve endotel hücrelerinde serbest oksijen radikallerinin aşırı üretimi, mitokondriyal deoksiribonükleik asit (DNA) hasarı, protein kinaz C aktivasyonu, poliol ve hekzoamin yolağı aktivasyonu, ileri glikozilasyon son ürünlerinin ve reseptörlerinin artışı gibi birçok mekanizma metabolik hafıza patogenezinde önemli rol oynamaktadır. Bu mekanizmalar, gen ekspresyonunu kalıcı olarak indükleyerek epigenetik değişikliklere neden olmaktadır. Metabolik hafıza; histon modifikasyonu, DNA metilasyonu ve mikro-ribonükleik asit (RNA) ile ilişkili mekanizmalar gibi epigenetik değişiklikler ile gerçekleşir. Klinik açıdan değerlendirildiğinde ise metabolik hafıza teorisi, metabolik kontrolü en kısa sürede sağlamak için erken ve yoğun tedavi rejiminin gerekliliğini vurgulamaktadır. Uzun süreli diyabetik komplikasyonları en aza indirgemek amacıyla erken ve yoğun hiperglisemi kontrolünün yanı sıra, reaktif oksijen türleri ve glikozilasyonu azaltabilen terapötik ajanlardan ve/veya epigenetik tedaviden de yararlanılabilir. Bu derlemede; metabolik hafıza teorisine, metabolik hafızanın tanımı ve patogenezine, epigenetik mekanizmalara ve terapötik yaklaşımlara yer verilmiştir.
Prediction of Linear Cationic Antimicrobial Peptides Active against Gram-Negative and Gram-Positive Bacteria Based on Machine Learning Models
(2022) Erdem Büyükkiraz, Mine; Söylemez, Ümmü Gülsüm; Yousef, Malik; Kesmen, Zülal; Bakir-Gungor, Burcu
Antimicrobial peptides (AMPs) are considered as promising alternatives to conventional antibiotics in order to overcome the growing problems of antibiotic resistance. Computational prediction approaches receive an increasing interest to identify and design the best candidate AMPs prior to the in vitro tests. In this study, we focused on the linear cationic peptides with non-hemolytic activity, which are downloaded from the Database of Antimicrobial Activity and Structure of Peptides (DBAASP). Referring to the MIC (Minimum inhibition concentration) values, we have assigned a positive label to a peptide if it shows antimicrobial activity; otherwise, the peptide is labeled as negative. Here, we focused on the peptides showing antimicrobial activity against Gram-negative and against Gram-positive bacteria separately, and we created two datasets accordingly. Ten different physico-chemical properties of the peptides are calculated and used as features in our study. Following data exploration and data preprocessing steps, a variety of classification algorithms are used with 100-fold Monte Carlo Cross-Validation to build models and to predict the antimicrobial activity of the peptides. Among the generated models, Random Forest has resulted in the best performance metrics for both Gram-negative dataset (Accuracy: 0.98, Recall: 0.99, Specificity: 0.97, Precision: 0.97, AUC: 0.99, F1: 0.98) and Gram-positive dataset (Accuracy: 0.95, Recall: 0.95, Specificity: 0.95, Precision: 0.90, AUC: 0.97, F1: 0.92) after outlier elimination is applied. This prediction approach might be useful to evaluate the antibacterial potential of a candidate peptide sequence before moving to the experimental studies.
Bazı Gıdalardaki Bozulma Etkeni Maya Türlerinin İzolasyonu ve Tanımlanması
(2020) Erdem Büyükkiraz, Mine; Avcı, Esra; Kahraman, Neslihan; Kesmen, Zülal
Gıdalarda bozulmaya neden olan mayaların belirlenmesi özellikle, kontaminasyon döngüsünün kırılması ve bozulma etkeni türlere özgü koruyucu önlemlerin alınması bakımından önemli görülmektedir. Bu nedenle bu çalışmada duyusal olarak tüketilebilirliğini kaybetmiş süt ürünleri, et ürünleri, taze meyve ve sebzeler, turşu ve salamura ürünler olmak üzere farklı gıda gruplarına ait örneklerin maya profilleri tespit edilmiştir. Bu amaçla yerel marketlerden, halk pazarlarından ve ev yapımı ürünlerden toplanan toplam 86 örnek analiz edilmiştir. Analiz edilen örneklerden izole edilen toplam 1032 maya izolatı tanımlanmıştır. Bunun için her bir örnekten saflaştırılan maya izolatları, tekrarlayan dizilere dayalı PCR (rep-PCR) yöntemiyle gruplandırılmıştır. Daha sonra her bir grubu temsil edecek sayıda izolat 26 S ribozomal DNA üzerindeki 665 bç’lik bölge (D1/D2 bölgesi) ve ribozomal DNA’nın transkript olan ara bölgesini (ITS) hedef alan dizi analizi yöntemi ile tanımlanmıştır. Tanımlanan izolatların dağılımı üründen ürüne değişmekle birlikte Pichia fermentans (% 11.60) ve Debaryomyces hansenii (% 11.50) tüm izolatlar içerisinde sayıca en baskın türler olarak bulunmuş ve bu türleri Candida zeylanoides (% 10.08) ve Kluyveromyces marxianus (% 8.04) takip etmiştir. Sonuçta her bir örnek grubundaki baskın maya türleri belirlenmiş ve analiz edilen gıda gruplarına özgü maya profilleri elde edilmiştir.
Recombinant expression and coexpression of oyster defensin and proline-rich peptide in Komagataella phaffii
(Biotechnology and Applied Biochemistry, 2021) Erdem Büyükkiraz, Mine; Kesmen, Zülal
Proline-rich peptide (CgPrp) and defensin (CgDef), oyster (Crassostrea gigas)-originated antimicrobial peptides (AMPs), were produced by the recombinant technique in Komagataella phaffii GS115 cells. For this purpose, the nucleotide sequences encoding the CgPrp and CgDef peptides were synthesized by the recursive PCR technique, and ligated in pPICZaA expression vector. Additionally, the expression cassettes of pPICZ?A-CgDef and pPICZ?A-CgPrp were combined using in vitro multimer ligation strategy to construct the coexpression vector pPICZaA-CgPrp-CgDef. The expression and coexpression vectors transformed into K. phaffii GS115 cells by electroporation. At the end of the 0.5% methanol-induced expression stage for 96 h, the recombinant peptides were purified from the culture medium. The concentrations of purified peptides were changed between 1.05 and 1.21 mg/L. The recombinant peptides successfully inhibited the growth of tested Gram-positive bacterial strains belonging to Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Listeria monocytogenes, and Bacillus cereus. The minimum inhibitory concentrations (MIC) of recombinant CgPrp, CgDef, and CgPrp-CgDef peptides against tested bacteria were in the range of 12.50–25.00, 18.75–75.00, and 5.80–11.60 pg/?l, respectively. The results of the study proved that the recombinant CgPrp, CgDef, and CgPrp-CgDef peptides expressed in K. phaffii might have good potential for the inhibition of common Gram-positive pathogenic bacteria, including drug-resistant MRSA.

Güncel Gönderiler