Investigation of the Protective Effects of Caffeic Acid Phenethyl Ester against Cisplatin-induced Liver Damage in Rats

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dc.authorid0000-0002-0917-0378
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorYakan, Birkan
dc.date.accessioned2021-04-02T06:31:06Z
dc.date.available2021-04-02T06:31:06Z
dc.date.issued2021en_US
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Patoloji Laboratuvar Teknikleri Bölümü
dc.description.abstractCisplatin (CP) is used as an effective chemotherapeutic drug in the treatment of various solid tumors. However, side effects such as hepatotoxicity limit the use of the drug. We investigated the protective effects of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, against hepatotoxicity caused by CP treatment in the liver. 38 Wistar albino rats were divided into 4 groups. Control group was given physiological saline solution for 12 day. CP group was given a single dose of CP (7 mg/kg) on the day 7. CP+CAPE group, was given CAPE (10 ?mol/kg/day) for 12 days and a single dose of CP (7 mg/kg) on day 7. CAPE group received CAPE (10 ?mol/kg/day) for 12 days. Livers of rats sacrificed on the 14th day were stained with hematoxylin-eosin after histological tissue follow-up. The preparations were evaluated and scored. Rat weights were measured and recorded at the beginning and end of the experiment. CP caused significant histopathological changes in the liver. CP also prevented the increase in rat weight. CAPE played an effective role as a protective agent against the histopathological changes caused by CP and showed signs of tissue healing. Our results show that CAPE can be protective against hepatotoxicity associated with CP.
dc.identifier.citationCEYLAN, T., & YAKAN, B. (2021). Investigation of the Protective Effects of Caffeic Acid Phenethyl Ester against Cisplatin induced Liver Damage in Rats. Experimental and Applied Medical Science, 2(1), 128–135.
dc.identifier.endpage135en_US
dc.identifier.issue1en_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12695/1014
dc.identifier.urihttps://doi.org/10.46871/eams.2021.16
dc.identifier.volume2en_US
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.relation.ispartofExperimental and Applied Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaffeic acid phenethyl ester
dc.subjectCisplatin
dc.subjectHepatotoxicity
dc.subjectLiver damage
dc.subjectRat
dc.titleInvestigation of the Protective Effects of Caffeic Acid Phenethyl Ester against Cisplatin-induced Liver Damage in Rats
dc.typeArticle

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