In vitro ?-glucosidase, docking and density functional theory studies on novel azide metal complexes
| dc.authorid | 0000-0001-9307-900X | |
| dc.contributor.author | Avcı, Davut | |
| dc.contributor.author | Özge, Özgen | |
| dc.contributor.author | Sönmez, Fatih | |
| dc.contributor.author | Tamer, Ömer | |
| dc.contributor.author | Başoğlu, Adil | |
| dc.contributor.author | Atalay, Yusuf | |
| dc.contributor.author | Zengin Kurt, Belma | |
| dc.date.accessioned | 2024-07-23T07:37:27Z | |
| dc.date.available | 2024-07-23T07:37:27Z | |
| dc.date.issued | 2024 | en_US |
| dc.department | Kapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Optisyenlik Bölümü | |
| dc.description.abstract | The goal of this study is to synthesize new metal complexes containing N-methyl-1-(pyridin-2-yl)methanimine and azide ligands as ?-glucosidase inhibitors for Type 2 diabetes. Materials & methods: The target complexes (12–16) were synthesized by reacting N-methyl-1-(pyridin-2-yl)methanimine (L1) with sodium azide in the presence of corresponding metal salts. The investigation of target protein interactions, vibrational, electronic and nonlinear optical properties for these complexes was performed by molecular docking and density functional theory studies. Results: Among these complexes, complex 13 (IC50 = 0.2802 ± 0.62 ?M) containing Hg ion showed the highest ?-glucosidase inhibitory property. On the other hand, significant results were detected for complexes containing Cu and Ag ions. Conclusion: Complex 13 may be an alternate anti-diabetic inhibitor according to in vitro/docking results. | |
| dc.identifier.issue | 11 | en_US |
| dc.identifier.uri | https://doi.org/10.1080/17568919.2024.2342650 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12695/2816 | |
| dc.identifier.volume | 16 | en_US |
| dc.institutionauthor | Özge, Özgen | |
| dc.language.iso | en | |
| dc.publisher | Future Medicinal Chemistry | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by-nd/4.0/ | * |
| dc.subject | ?-glucosidase/dockingazide | |
| dc.subject | Cu/Hg/Cd/Ag/Zn ions | |
| dc.subject | Schiff base | |
| dc.subject | spectral elucidation | |
| dc.subject | TD/DFT methods | |
| dc.title | In vitro ?-glucosidase, docking and density functional theory studies on novel azide metal complexes | |
| dc.type | Article |
