Histological evaluation of the effects of rapamycin and 3-methyladenine on cisplatin-induced epididymal injury in rats

Basit Öğe Kaydı
dc.authorid0000-0002-0917-0378
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorKarabulut, Derya
dc.contributor.authorÖztürk, Emel
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorKaymak, Emin
dc.contributor.authorYakan, Birkan
dc.date.accessioned2021-07-30T06:23:21Z
dc.date.available2021-07-30T06:23:21Z
dc.date.issued2021en_US
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Patoloji Laboratuvar Teknikleri Bölümü
dc.descriptionTARAMAWOS
dc.description.abstractPurpose: In this study, we aimed to determine the effects of autophagy inhibitor and activator on Cisplatin (Cis)-induced tissue damage. Materials and Methods: A total of 24 male Wistar albino rats were divided into 4 groups including 6 rats per group in this study. Groups are as follows; Control, Cisplatin (Cis) (8 mg/kg), Rapamycin (Rapa) (2 mg/kg), 3-methyladenine (3-MA) (15 mg/kg). Rapa and 3-MA were given intraperitoneally for 15 days. Cis was administered as a single dose on the 7th day of the experimental period. At the end of the experimental procedure, epididymis tissues were extracted. Hematoxylin and eosin staining and Heat shock protein-70 (HSP70) immunohistochemistry were applied to the sections taken after histological techniques. Results: Dispersion in the tubule basement membrane and vacuolization in the tubule was observed in the Cis group. It was also observed that some epithelial cells were more eosinophilic in the Cis group. Tissue sections of Rapa and 3-MA had a more regular appearance in terms of epithelization and tubule basement membrane. HSP70 immunoreactivity was observed in the intertubuler connective tissue of all groups. Conclusion: The epididymis was affected by agents such as Cis in terms of the protection of semen quality and potency of spermatozoa. Rapa may be more effective than 3-MA in the epididymis against Cis toxicity.
dc.identifier.citationCEYLAN, T., KARABULUT, D., ÖZTÜRK, E., AKİN, A. T., KAYMAK, E., & YAKAN, B. (2021). Histological evaluation of the effects of rapamycin and 3-methyladenine on cisplatin-induced epididymal injury in rats. Cukurova Medical Journal, 46(3), 1184–1190.
dc.identifier.endpage1190en_US
dc.identifier.issue3en_US
dc.identifier.startpage1184en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.924352
dc.identifier.urihttps://hdl.handle.net/20.500.12695/1231
dc.identifier.volume46en_US
dc.identifier.wosWOS:000695272700038
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.publisherCukurova Medical Journal
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutophagy
dc.subjectCisplatin
dc.subjectEpididymis
dc.subjectRapamycin
dc.subject3-methyladenin
dc.titleHistological evaluation of the effects of rapamycin and 3-methyladenine on cisplatin-induced epididymal injury in rats
dc.title.alternativeSisplatin-indüklenmiş sıçan epididimis dokusunda rapamisin ve 3-metiladeninin etkilerinin histolojik olarak değerlendirilmesi
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
10.17826-cumj.924352-1724204 - TC.pdf
Boyut:
349.55 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale / Article
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PLT - Makale Koleksiyonu