Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications

Basit Öğe Kaydı
dc.contributor.authorIlhan, Elif
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorKılıçay, Ebru
dc.contributor.authorHazer, Baki
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned2020-05-21T01:27:37Z
dc.date.available2020-05-21T01:27:37Z
dc.date.issued2020
dc.departmentKapadokya Üniversitesi
dc.descriptionTARAMASCOPUS
dc.descriptionTARAMAWOS
dc.description.abstractPostoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (beta-TCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity of the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 beta-TCP) w/w in beta-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects.
dc.description.sponsorshipBulent Ecevit UniversityBulent Ecevit University [BEU-2016-33496813-02]
dc.description.sponsorshipThe authors would like to thank Murat Demirbilek for helping with antibacterial assays. Our special thanks go to Geliim Medikal and Oliga Ltd., Turkey for providing us with the PMMA and beta-TCP samples used in this study. This work was supported by grant from the Bulent Ecevit University (BEU-2016-33496813-02).
dc.identifier.doi10.1080/10667857.2019.1661157
dc.identifier.endpage194en_US
dc.identifier.issn1066-7857
dc.identifier.issn1753-5557
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage179en_US
dc.identifier.urihttps://doi.org/10.1080/10667857.2019.1661157
dc.identifier.urihttps://hdl.handle.net/20.500.12695/38
dc.identifier.volume35en_US
dc.identifier.wosWOS:000487927500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofMaterials Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectBone cement
dc.subjectpolystyrene
dc.subjectsilver nanoparticle
dc.subjectsoybean oil
dc.titlePotent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications
dc.typeArticle

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