Effects of Nitric Oxide Synthase-1 Exon 1f-VNTR Gene Polymorphism on the Clinical Symptoms of Alcohol Dependence, Impulsivity and Comorbid Attention Deficit Hyperactivity Disorder

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dc.contributor.authorKarakaya, İbrahim
dc.contributor.authorGürel, Şeref Can
dc.contributor.authorAyhan, Yavuz
dc.contributor.authorKaşifoğlu, Mehmet Ali
dc.contributor.authorKarahan, Sevilay
dc.contributor.authorBabaoğlu, Melih
dc.contributor.authorDemir, Başaran
dc.date.accessioned2020-05-21T01:27:36Z
dc.date.available2020-05-21T01:27:36Z
dc.date.issued2019
dc.departmentKapadokya Üniversitesi, Beşeri Bilimler Fakültesi, Psikoloji Bölümü
dc.descriptionGurel, Seref Can/0000-0003-3261-6611
dc.descriptionTARAMASCOPUS
dc.descriptionTARAMAPUBMED
dc.descriptionTARAMAWOS
dc.descriptionTARAMATRDİZİN
dc.description.abstractObjective: We planned to compare individuals with alcohol dependence (AD) and healthy controls on the frequency of NOS1 exon 1f-VNTR gene polymorphism and to investigate the effects of this polymorphism on the clinical symptoms of alcohol dependence, impulsiveness and comorbid attention deficit hyperactivity disorder (ADHD) symptoms. Method: A total of 282 participants consisting of 153 patients and 129 age and gender matched healthy individuals were inluded in the study. All participants were evaluated with Structured Clinical Interview for DSM-IV Axis 1 disorders (SCID-I) and Michigan Alcohol Screening Test (MAST), Barratt Impulsiveness Scale (BIS-11), UPPS Impulsive Behavior Scale, Adult Attention Deficit and Hyperactivity Diagnosis Scale (ADHDS), Family History Research Diagnostic Criteria (FHDRC). The QF-PCR fragment protocols were used for genetic analyses. Allele fragments of <= 176 bp and >176 bp sizes were separated and 3 different genotypes were determined as the SS, SL and LL. Associations of these genotypes with symptoms of AD severity, impulsiveness and comorbid ADHD were investigated. Results: The AD and control groups did not differ significantly on the basis of NOS1 exon 1f-VNTR gene polymorphism. Also, significant correlations between this polymorphism and symptoms of AD severity, impulsiveness and ADHD were not determined. Conclusion: Results of our study do not indicatea significant association between the NOS1 exon 1f-VNTR genotypes and AD, subgroups of AD, impulsiveness or comorbid ADHD semptoms.
dc.identifier.doi10.5080/u22980
dc.identifier.endpage89en_US
dc.identifier.issn1300-2163
dc.identifier.issue2en_US
dc.identifier.pmid31487373
dc.identifier.scopusqualityQ3
dc.identifier.startpage82en_US
dc.identifier.urihttps://doi.org/10.5080/u22980
dc.identifier.urihttps://hdl.handle.net/20.500.12695/33
dc.identifier.volume30en_US
dc.identifier.wosWOS:000496714500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegi
dc.relation.ispartofTurk Psikiyatri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectAlcohol dependence
dc.subjectAttention deficit hyperactivity disorder
dc.subjectNitric oxide synthase
dc.subjectImpulsiveness
dc.titleEffects of Nitric Oxide Synthase-1 Exon 1f-VNTR Gene Polymorphism on the Clinical Symptoms of Alcohol Dependence, Impulsivity and Comorbid Attention Deficit Hyperactivity Disorder
dc.typeArticle

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