Michael/Michael Addition Cascade of 2-Benzylidene-1-indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds

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dc.contributor.authorGezegen, Hayreddin
dc.contributor.authorTutar, Uğur
dc.contributor.authorTüzün, Gamze
dc.contributor.authorAtioğlu, Zeliha
dc.contributor.authorAkkurt, Mehmet
dc.date.accessioned2022-03-18T14:23:35Z
dc.date.available2022-03-18T14:23:35Z
dc.date.issued2021en_US
dc.departmentKapadokya Üniversitesi, Uygulamalı Bilimler Yüksekokulu, Havacılık Elektrik ve Elektroniği Bölümü
dc.descriptionTARAMAWOS
dc.descriptionTARAMASCOPUS
dc.description.abstractA series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2-benzylidene-1-indanones with chalcones in high yields. This method provides an efficient route for the synthesis of a new class of polycyclic compounds have five stereo centers. The obtained polycyclic compounds were evaluated for the antimicrobial and anticancer activities against fifteen microorganism and three cell lines. The compound 3 r have the best activity value against the cells (MCF-7 IC50=18.01 +/- 0.39 mu g/mL) (MDA-MB- 231 IC50=18.78 +/- 1.75 mu g/mL) (MCF-10 A IC50=31.31 +/- 0.05 mu g/mL).
dc.identifier.endpage9631en_US
dc.identifier.issn2365-6549
dc.identifier.issue36en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage9625en_US
dc.identifier.urihttps://doi.org/10.1002/slct.202102738
dc.identifier.urihttps://hdl.handle.net/20.500.12695/1542
dc.identifier.volume6en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAtioğlu, Zeliha
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial
dc.subjectAnticancer
dc.subject2-Benzylidene-1-indanone
dc.subjectChalcone
dc.subjectMichael addition
dc.titleMichael/Michael Addition Cascade of 2-Benzylidene-1-indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
dc.typeArticle

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