Protective effect of melatonin on cisplatin-induced liver injury in rats

Basit Öğe Kaydı
dc.authorid0000-0002-0917-0378
dc.contributor.authorKaymak, Emin
dc.contributor.authorÜnsal, Murat
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorÖztürk, Emel
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorKuloğlu, Nurhan
dc.contributor.authorKarabulut, Derya
dc.contributor.authorYakan, Birkan
dc.date.accessioned2022-03-08T14:41:38Z
dc.date.available2022-03-08T14:41:38Z
dc.date.issued2022en_US
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Patoloji Laboratuvar Teknikleri Bölümü
dc.description.abstractPurpose: We aimed to evaluate the protective effect of melatonin (Mel) on experimental hepatatoxicity induced by cisplatin (Cis). Materials and Methods: A total of 40 Wistar Albino rats were used. Control group (n = 10) daily 0.1 mg / kg isotonic solution (intraperitoneal) i.p. was administered. Cis group (n = 10) was given a single dose of i.p. Cis (7 mg/kg) was administered. Melatonin (Mel) group (n = 10) daily i.p. Mel (10 mg / kg) was administered. Cis + Mel group (n = 10) daily i.p. Mel (10 mg / kg) + single dose i.p. Cis (7mg / kg) was administered. On the 8th day of the experiment, liver tissues of rats were collected histologically and immunohistochemically for tumor necrosis factor-? (TNF-?) analysis. Analyzes were performed for the levels of Alanine aminotransferase (ALT), aspartate aminotransferase (AST), Lactate dehydrogenase (LDH), and albumin for liver function from the serum obtained from the blood. Results: It was observed that liver tissue histopathological score and TNF-? immunoreactivity increased significantly with cisplatin administration compared to the control group. We found that the histopathological score and TNF-? immunoreactivity were decreased in the group treated with melatonin, and the liver function enzymes ALT, AST, and LDH were significantly decreased compared to the cisplatin group. Albumin level, on the other hand, showed a significant improvement in the group treated with melatonin. Conclusion: Melatonin may play a protective role in hepatotoxicity caused by cisplatin by reducing inflammation and preventing the increase in liver enzymes.
dc.identifier.citationKAYMAK, E., ÜNSAL, M., ÖZTÜRK, E., AKİN, A. T., CEYLAN, T., KULOĞLU, N., … YAKAN, B. (2022). Protective effect of melatonin on cisplatin-induced liver injury in rats. Cukurova Medical Journal, 47(1), 250–258.
dc.identifier.endpage258en_US
dc.identifier.issue1en_US
dc.identifier.startpage250en_US
dc.identifier.urihttps://10.17826/cumj.1029473
dc.identifier.urihttps://hdl.handle.net/20.500.12695/1527
dc.identifier.volume47en_US
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.publisherCukurova Medical Journal
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatin
dc.subjectInflammation
dc.subjectMelatonin
dc.titleProtective effect of melatonin on cisplatin-induced liver injury in rats
dc.title.alternativeMelatoninin sıçanlarda cisplatin kaynaklı karaciğer hasarı üzerindeki koruyucu etkisi
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Protective effect of melatonin on cisplatin-induced liver injury in rats.pdf
Boyut:
986.57 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale / Article
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PLT - Makale Koleksiyonu