PLinaS-g-PEG Coated Magnetic Nanoparticles as a Contrast Agent for Hepatocellular Carcinoma Diagnosis

Basit Öğe Kaydı
dc.authorid0000-0001-8770-805X
dc.contributor.authorHazer, Baki
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorKılıçay, Ebru
dc.date.accessioned2020-08-04T13:40:21Z
dc.date.available2020-08-04T13:40:21Z
dc.date.issued2020en_US
dc.departmentKapadokya Üniversitesi, Uygulamalı Bilimler Yüksekokulu, Uçak Gövde ve Motor Bakımı Bölümü
dc.descriptionSCI-E, Web of Science
dc.descriptionTARAMAWOS
dc.descriptionTARAMAPUBMED
dc.descriptionTARAMASCOPUS
dc.description.abstractAmong many different types of fabricated nanoparticles, magnetic iron oxide nanoparticles (MNPs) have unique physical and chemical properties and have been widely used due to theirs enhanced permeability and retention effect for biomedical applications. The incorporated theranostic MNPs into biopolymer coatings are currently particular interest to investigators in the fields of nanobiomedicine because of efficiently delivering of various drugs, genes and providing imaging properties. Hepatocellular carcinoma (HCC) is the most prevalent reason of cancer-related deaths, makes it one of the worst malignant tumors in the world. Because, there is a lack of effective treatment methods for HCC, aforementioned magnetic carrier technology with recent innovations could be a promising tool in HCC diagnosis and treatment. Therefore, this study proposes a novel fatty-acid-based polymeric magnetic nanoprobe for diagnosis of hepatocellular tumors using polyethylene glycol (PEG)-terminated polystyrene (PS)-linoleic copolymer coated magnetic iron oxide nanoparticles. MNPs were synthesized by a co-precipitation method and were subsequently coated with a copolymer containing PEG group as termini. Fifty-nanometersized MNPs were incorporated into the core of PLinaS-g-PEG nanoparticles. The morphology and size distribution of the bare and magnetic PLinaS-g-PEG were determined by transmission electron microscopy (TEM), and dynamic light scattering (DLS), respectively. MTT and flow cytometry assays showed that PLinaSg- PEG MNPs demonstrated ultrasentive apoptotic behavior against cancerous cell line, i.e. HepG2 in the culture plate when the fatty acid-containing polymer coated MNPs showed no adverse effect on L929 cell growth. The localization, and accumulation in hepatocytes of PLinaS-g-PEG MNPs without specific targeting ligand was confirmed by fluorescence and confocal microscopy. Therefore, PLinaS-g-PEG MNPs may be potentially used as a unique candidate for diagnosis of hepatocellular carcinomas.
dc.identifier.citationKarahaliloğlu, Z. Kılıçay, E. Hazer, B. (2020), PLinaS-g-PEG Coated Magnetic Nanoparticles As a Contrast Agent For Hepatocellular Carcinoma Diagnosis, Journal of Biomaterials Science, Polymer Edition,
dc.identifier.doi10.1080/09205063.2020.1764183
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12695/690
dc.identifier.urihttps://doi.org/10.1080/09205063.2020.1764183
dc.identifier.volume31en_US
dc.identifier.wosWOS:000544194100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHazer, Baki
dc.language.isoen
dc.publisherTaylor Francis
dc.relation.ispartofJournal of Biomaterials Science, Polymer Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectContrast agent
dc.subjectdiagnosis
dc.subjecthepatocellular carcinoma
dc.subjectlinoleic acid
dc.subjectnanoparticle
dc.titlePLinaS-g-PEG Coated Magnetic Nanoparticles as a Contrast Agent for Hepatocellular Carcinoma Diagnosis
dc.typeArticle

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