The Ameliorative Effects of Caffeic Acid Phenethyl Ester in Cisplatin-Induced Nephrotoxicity: Assessment of the Oxidative Stress an Inflammation

Basit Öğe Kaydı
dc.authorid0000-0002-0917-0378
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorKaymak, Emin
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorYakan, Birkan
dc.date.accessioned2021-04-02T06:28:36Z
dc.date.available2021-04-02T06:28:36Z
dc.date.issued2021en_US
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Patoloji Laboratuvar Teknikleri Bölümü
dc.descriptionTARAMAWOS
dc.descriptionTARAMASCOPUS
dc.description.abstractThe aim of this study is to determine the potential therapeutic effects of CAPE in CP-induced nephrotoxicity in rats. Cisplatin (CP) is an antineoplastic chemotherapeutic used for treatment of many cancer types but its applications may induce nephrotoxicity. Caffeic acid phenethyl ester (CAPE) is an active component of propolis and it has several important physiological activities. Rats were divided into four groups: Control, CAPE (10 mmol/kg/i.p), CP (7 mg/kg/i.p), and CP+CAPE (7 mg/kg/i.p, CP and 10 mmol/kg/i.p, CAPE). After administrations, animals were sacrificed, and kidney tissues were extracted. Histopathological changes were evaluated and TNF-a and IL-6 immunostaining were performed. Moreover, tissue SOD, CAT and MDA levels were measured by ELISA assay to assessment of oxidative stress and lipid peroxidation. CP group showed histopathological deterioration compared to the Control group and CAPE treatment attenuated this damage. When compared with Control and CAPE group, an increase in TNF-a and IL-6 immunoreactivities and tissue MDA levels were observed in the CP group while a decrease in tissue SOD and CAT levels were detected. Furthermore, an improvement was observed in the CP+CAPE compared to the CP group. We suggest that CAPE can be used as a therapeutic agent to attenuate the toxic effects of cisplatin, thanks to its antioxidant and anti-inflammatory properties.
dc.identifier.citationCEYLAN, T., KAYMAK, E., AKİN, A. T., & YAKAN, B. (2021). The Ameliorative Effects of Caffeic Acid Phenethyl Ester in Cisplatin Induced Nephrotoxicity Assessment of the Oxidative Stress an Inflammation. International Journal of Morphology, 39(2), 612–618.
dc.identifier.doi10.4067/S0717-95022021000200612
dc.identifier.endpage618en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage612en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12695/1013
dc.identifier.volume39en_US
dc.identifier.wosWOS:000644964900041
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatin
dc.subjectCaffeic acid phenethyl ester
dc.subjectInflammation
dc.subjectOxidative stress
dc.titleThe Ameliorative Effects of Caffeic Acid Phenethyl Ester in Cisplatin-Induced Nephrotoxicity: Assessment of the Oxidative Stress an Inflammation
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale / Article
Boyut:
317.1 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Patoloji Laboratuvar Teknikleri - Makale Koleksiyonu