Browsing by Author "Kaymak, Emin"
Now showing items 1-20 of 29
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The Ameliorative Effects of Caffeic Acid Phenethyl Ester in Cisplatin-Induced Nephrotoxicity: Assessment of the Oxidative Stress an Inflammation
The aim of this study is to determine the potential therapeutic effects of CAPE in CP-induced nephrotoxicity in rats. Cisplatin (CP) is an antineoplastic chemotherapeutic used for treatment of many cancer types but its ... -
Anti-inflammatory and anti-apoptotic effects of naringin on bacterial endotoxin-induced small intestine damage in rats
Akin, Ali Tuğrul; El Bechir, Mohamed Lemine; Kaymak, Emin; Ceylan, Tayfun; Sayan, Meryem; Değer, Necla; Karabulut, Derya; Toluk, Ayşe (2022)Purpose: The aim of this study is to investigate the anti inflammatory and anti-apoptotic effects of naringin (NRG), which has many biological properties, on bacterial endotoxin-induced small intestine damage in rats. ... -
Chloroquine attenuates chronic hypoxia-induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model
Akin, Ali Tuğrul; Kaymak, Emin; Ceylan, Tayfun; Öztürk, Emel; Başaran, Kemal Erdem; Karabulut, Derya; Özdamar, Saim; Yakan, Birkan (Wiley Online Library, 2022)Chronic hypoxia negatively affects male fertility by causing pathological changes in male reproductive system. However, underlying mechanisms of this damage are unknown. Chloroquine (CLQ) is an anti-inflammatory agent that ... -
Comparison of the Acute and Cumulative Dose Administrations in Doxorubicin-induced Hepatotoxicity via Evaluation of the Histopathological Changes and Inflammation in Rats
Akin, Ali Tuğrul; Kaymak, Emin; Karabulut, Derya; Doğanyiğit, Züleyha; Ceylan, Tayfun; Toluk, Ayşe; Özdamar, Saim (Experimental and Applied Medical Science, 2020)Doxorubicin (DOX) may lead to hepatotoxicity when administered chronically or in a high dose. The aim of this study is to determine dose–dependent effects of DOX in rat liver tissue. Thirty male Wistar albino rats were ... -
Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway
Akin, Ali Tuğrul; Ceylan, Tayfun; Kaymak, Emin (2022)Acute lung injury (ALI) is a frequent consequence which has high morbidity and mortality in sepsis. The most significant pathogen hypothesized to be causing the formation of ALI in sepsis is thought to be lipopolysaccharide ... -
Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway
Ceylan, Tayfun; Akin, Ali Tuğrul; Kaymak, Emin; Varinli, Şaban; Toluk, Ayşe (DergiPark, 2024)Background and Purpose: The most significant pathogen hypothesized to be causing the formation of Acute lung injury (ALI) in sepsis is thought to be lipopolysaccharide (LPS), a key endotoxin component of gram-negative ... -
The Dose-Dependent Effects Of Doxorubicin In Ratliver Tissue
Akin, Ali Tuğrul; Kaymak, Emin; Karabulut, Derya; Doğanyiğit, Züleyha; Ceylan, Tayfun; Toluk, Ayşe; Özdamar, Saim (1st International Ahi Evran Medical and Health Science Congress (IAMHC), 2019)Introduction: Doxorubicin (DOX) is an anthracycline antibiotic used as an anticancer agent and is a widely used chemotherapeutic for many cancer types such as sarcoma, acute lymphoblastic leukaemia and as well as breast ... -
Effect of Chloroquine in Chronic Hypoxia-Induced Bowel Damage
Kaymak, Emin; Akin, Ali Tuğrul; Yalçın, Betül; Öztürk, Emel; Ceylan, Tayfun; Başaran, Kemal Erdem; Karabulut, Derya; Doğanyiğit, Züleyha; Özdamar, Saim; Yakan, Birkan (20. Ulusal Anatomi Kongresi, 2019)Effect of chloroquine in chronic hypoxia-induced bowel damage -
Effect of thymoquinone on NRF2/NF-kB/MAPK pathway in methotrexate-induced rat testis injury
Kaymak, Emin; Ceylan, Tayfun; Akin, Ali Tuğrul; Kuloğlu, Nurhan; Sayan, Meryem; Değer, Necla; Önal, Esra; Yıldırım, Ayşegül Burçin; Karabulut, Derya (Iranian Journal of Basic Medical Sciences, 2024)Objective(s): In this study, we aimed to investigate the protective effect of Thymoquinone (THQ) against testicular damage caused by Methotrexate (MTX). Materials and Methods: This study consists of 5 groups: Control, ... -
Effect of vitamin B12 on methotrexate-induced cardiotoxicity in rats
Kuloğlu, Nurhan; Karabulut, Derya; Kaymak, Emin; Akin, Ali Tuğrul; Ceylan, Tayfun; Yıldırım, Ayşegül Burçin; Yakan, Birkan (Iranian Journal of Basic Medical Sciences, 2024)Objective(s): Methotrexate (MTX) is a drug with anti-inflammatory and immunosuppressive effects and is also a folic acid antagonist. Our aim in this study is to determine the molecular mechanisms of cardiotoxicity caused ... -
Evaluation Of Epididymitis Tissue Of Cisplatin-Induced Rats
Ceylan, Tayfun; Karabulut, Derya; Öztürk, Emel; Akin, Ali Tuğrul; Kaymak, Emin; Yakan, Birkan (SANAR, 2020)As a chemotherapeutic agent, cisplatin is an antineoplastic agent used in the treatment of various solid tumors such as lung, testicle and bladder cancer (Ezaki, Nishiumi, Azuma, & Yoshida, 2017; Salem, Helmi, & Assaf, ... -
Histological evaluation of the effects of rapamycin and 3-methyladenine on cisplatin-induced epididymal injury in rats
Ceylan, Tayfun; Karabulut, Derya; Öztürk, Emel; Akin, Ali Tuğrul; Kaymak, Emin; Yakan, Birkan (Cukurova Medical Journal, 2021)Purpose: In this study, we aimed to determine the effects of autophagy inhibitor and activator on Cisplatin (Cis)-induced tissue damage. Materials and Methods: A total of 24 male Wistar albino rats were divided into 4 ... -
Histopathological Changes In Lung Tissue Caused By Diabetes: A Review
Burçin Yıldırım, Ayşegül; Karabulut, Derya; Kaymak, Emin; Kuloğlu, Nurhan; Akin, Ali Tuğrul; Ceylan, Tayfun; Öztürk, Emel (DergiPark, 2023)Diabetes mellitus associated with oxidative stress and inflammation can affect many organs. While the effects of diabetes on many organs are well known and documented, its mechanisms of action on the lung are known far ... -
Investigation of the Effect of Chloroquine on Adriamcycin-Induced Kidney Damage
Although Adriamycin (ADR) is an important anticancer drug used in chemotherapy, it causes nephrotoxicity. The inflammation pathway has an important role in ADR-induced nephrotoxicity. Chloroquine (CLQ), which is used as ... -
Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions
Yıldırım, Ayşegül Burçin; Değer, Necla; Sayan, Meryem; Akin, Ali Tuğrul; Ceylan, Tayfun; Kaymak, Emin; Kara, Mehmet; Ünsal, Murat; Karabulut, Derya (Experimental and Applied Medical Science, 2023)This study aimed to determine whether thymoquinone has any protective effects on renal tissue after an isoproterenol-induced myocardial infarction (MI). Experimental groups were formed as 4 groups (n=8). Control group (C). ... -
Investigation of the Therapeutic Effects of Chloroquine in Adriamycin-Induced Hepatotoxicity
Akin, Ali Tuğrul; Kaymak, Emin; Öztürk, Emel; Karabulut, Derya; Kuloğlu, Nurhan; Ceylan, Tayfun; Toluk, Ayşe (Sciendo, 2021)The aim of this study is to investigate the therapeutic effects of Chloroquine (CLQ) against Adriamycin (ADR) induced hepatotoxicity. ADR is a chemotherapeutic agent used in the treatment of many cancer types, but it causes ... -
Kadmiyum Uyarılı Testis Hasarına Karşı Timokinon’un Koruyucu Etkisi
Ceylan, Tayfun; Kaymak, Emin; Varinli, Şaban; Akin, Ali Tuğrul (16. Ulusal Histoloji ve Embriyoloji Kongresi, 2024)Giriş: Metaller, günlük yaşamda mesleki olarak veya çevredeki doğal varlıklarıyla karşılaşılan önemli bir toksik element sınıfı olarak bilinmektedir (1). Toksik ağır metallerden biri olan kadmiyumun (Cd) artan üretimi ve ... -
Klorokuin endoplazmik retikulum stresini ve enflamasyonu inhibe ederek sıçanlarda adriamisin uyarılı kardiyotoksisiteyi engeller
Kaymak, Emin; Akin, Ali Tuğrul; Öztürk, Emel; Ceylan, Tayfun; Kuloğlu, Nurhan; Karabulut, Derya; Yakan, Birkan (Türk Hijyen ve Deneysel Biyoloji Dergisi, 2020)Amaç: Adriamisin (ADR) kanser türlerinde kullanılan kemoterapötik bir ilaç olarak bilinmektedir. ADR uyarılı kardiyomiyopati toksik özelliğinden dolayı ilacın kullanımını zorlaştırmaktadır. ADR uyarılı kardiyotoksisitede ... -
Kronik Hipoksiye Maruz Bırakılan Ratlardaki Mide Ghrelin Miktarı Üzerine Klorokuin’in Etkisi
Kaymak, Emin; Akin, Ali Tuğrul; Öztürk, Emel; Yalçın, Betül; Ceylan, Tayfun; Başaran, Kemal Erdem; Doğanyiğit, Züleyha; Karabulut, Derya; Özdamar, Saim; Yakan, Birkan (2019)Giriş Amaç Yüksek irtifada yaşanan komplikasyonlardan biri olan Anoreksiya, çevresel durumu sinyallerde enerji durumunu belirleyen ve iştahı kontrol eden hipoksinin neden olduğu rahatsızlıklardan kaynaklanmaktadır. ... -
Metotreksat Uyarılı Rat Testis Hasarında Timokinon'un Etkisi
Kaymak, Emin; Ceylan, Tayfun; Akin, Ali Tuğrul (2022)Giriş: Kemoterapi kanser tedavisinde kullanılmasıyla birlikte kemoterapi ilaçlarının yan etkileri de mevcuttur. Kemoterapide kullanılan ilaçlardan biri olan metotreksat (MTX) özellikle meme kanseri ve romatoid artritte ...
