Browsing by Author "Yakan, Birkan"
Now showing items 1-17 of 17
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The Ameliorative Effects of Caffeic Acid Phenethyl Ester in Cisplatin-Induced Nephrotoxicity: Assessment of the Oxidative Stress an Inflammation
The aim of this study is to determine the potential therapeutic effects of CAPE in CP-induced nephrotoxicity in rats. Cisplatin (CP) is an antineoplastic chemotherapeutic used for treatment of many cancer types but its ... -
Chloroquine attenuates chronic hypoxia-induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model
Akin, Ali Tuğrul; Kaymak, Emin; Ceylan, Tayfun; Öztürk, Emel; Başaran, Kemal Erdem; Karabulut, Derya; Özdamar, Saim; Yakan, Birkan (Wiley Online Library, 2022)Chronic hypoxia negatively affects male fertility by causing pathological changes in male reproductive system. However, underlying mechanisms of this damage are unknown. Chloroquine (CLQ) is an anti-inflammatory agent that ... -
Effect of Chloroquine in Chronic Hypoxia-Induced Bowel Damage
Kaymak, Emin; Akin, Ali Tuğrul; Yalçın, Betül; Öztürk, Emel; Ceylan, Tayfun; Başaran, Kemal Erdem; Karabulut, Derya; Doğanyiğit, Züleyha; Özdamar, Saim; Yakan, Birkan (20. Ulusal Anatomi Kongresi, 2019)Effect of chloroquine in chronic hypoxia-induced bowel damage -
Effect of vitamin B12 on methotrexate-induced cardiotoxicity in rats
Kuloğlu, Nurhan; Karabulut, Derya; Kaymak, Emin; Akin, Ali Tuğrul; Ceylan, Tayfun; Yıldırım, Ayşegül Burçin; Yakan, Birkan (Iranian Journal of Basic Medical Sciences, 2024)Objective(s): Methotrexate (MTX) is a drug with anti-inflammatory and immunosuppressive effects and is also a folic acid antagonist. Our aim in this study is to determine the molecular mechanisms of cardiotoxicity caused ... -
Evaluation Of Epididymitis Tissue Of Cisplatin-Induced Rats
Ceylan, Tayfun; Karabulut, Derya; Öztürk, Emel; Akin, Ali Tuğrul; Kaymak, Emin; Yakan, Birkan (SANAR, 2020)As a chemotherapeutic agent, cisplatin is an antineoplastic agent used in the treatment of various solid tumors such as lung, testicle and bladder cancer (Ezaki, Nishiumi, Azuma, & Yoshida, 2017; Salem, Helmi, & Assaf, ... -
Histological evaluation of the effects of rapamycin and 3-methyladenine on cisplatin-induced epididymal injury in rats
Ceylan, Tayfun; Karabulut, Derya; Öztürk, Emel; Akin, Ali Tuğrul; Kaymak, Emin; Yakan, Birkan (Cukurova Medical Journal, 2021)Purpose: In this study, we aimed to determine the effects of autophagy inhibitor and activator on Cisplatin (Cis)-induced tissue damage. Materials and Methods: A total of 24 male Wistar albino rats were divided into 4 ... -
Investigation of the Protective Effects of Caffeic Acid Phenethyl Ester against Cisplatin-induced Liver Damage in Rats
Ceylan, Tayfun; Yakan, Birkan (2021)Cisplatin (CP) is used as an effective chemotherapeutic drug in the treatment of various solid tumors. However, side effects such as hepatotoxicity limit the use of the drug. We investigated the protective effects of caffeic ... -
Klorokuin endoplazmik retikulum stresini ve enflamasyonu inhibe ederek sıçanlarda adriamisin uyarılı kardiyotoksisiteyi engeller
Kaymak, Emin; Akin, Ali Tuğrul; Öztürk, Emel; Ceylan, Tayfun; Kuloğlu, Nurhan; Karabulut, Derya; Yakan, Birkan (Türk Hijyen ve Deneysel Biyoloji Dergisi, 2020)Amaç: Adriamisin (ADR) kanser türlerinde kullanılan kemoterapötik bir ilaç olarak bilinmektedir. ADR uyarılı kardiyomiyopati toksik özelliğinden dolayı ilacın kullanımını zorlaştırmaktadır. ADR uyarılı kardiyotoksisitede ... -
Kronik Hipoksiye Maruz Bırakılan Ratlardaki Mide Ghrelin Miktarı Üzerine Klorokuin’in Etkisi
Kaymak, Emin; Akin, Ali Tuğrul; Öztürk, Emel; Yalçın, Betül; Ceylan, Tayfun; Başaran, Kemal Erdem; Doğanyiğit, Züleyha; Karabulut, Derya; Özdamar, Saim; Yakan, Birkan (2019)Giriş Amaç Yüksek irtifada yaşanan komplikasyonlardan biri olan Anoreksiya, çevresel durumu sinyallerde enerji durumunu belirleyen ve iştahı kontrol eden hipoksinin neden olduğu rahatsızlıklardan kaynaklanmaktadır. ... -
Mitigative effects of chloroquine treatment against hypoxia-induced intestinal injury: a histological and immunohistochemical study
Akin, Ali Tuğrul; Kaymak, Emin; Öztürk, Emel; Ceylan, Tayfun; Yalçın, Betül; Başaran, Kemal Erdem; Karabulut, Derya; Doğanyiğit, Züleyha; Özdamar, Saim; Yakan, Birkan (Türk Hijyen ve Deneysel Biyoloji Dergisi, 2022)Objective: Hypoxia has an important role in the disruption of intestinal mucosal integrity because of inflammation and apoptosis induced by inflammatory cytokines such as TNF-α (Tumor necrosis factor-alpha), IL-6 and ... -
Protective effect of melatonin on cisplatin induced acute kidney injury: Role of regulation of heat shock proteins expressions
Akin, Ali Tuğrul; Ünsal, Murat; Ceylan, Tayfun; Kaymak, Emin; Öztürk, Emel; Kuloğlu, Nurhan; Karabulut, Derya; Yakan, Birkan (Indian Journal of Experimental Biology, 2023)Chemotherapy is one of the major treatment approaches for cancer, and these agents are known to cause severe side effects, including damaging vital organs. Cisplatin (CP) is a commonly used chemotherapeutic agent in the ... -
Protective effect of melatonin on cisplatin-induced liver injury in rats
Kaymak, Emin; Ünsal, Murat; Akin, Ali Tuğrul; Öztürk, Emel; Ceylan, Tayfun; Kuloğlu, Nurhan; Karabulut, Derya; Yakan, Birkan (Cukurova Medical Journal, 2022)Purpose: We aimed to evaluate the protective effect of melatonin (Mel) on experimental hepatatoxicity induced by cisplatin (Cis). Materials and Methods: A total of 40 Wistar Albino rats were used. Control group (n = 10) ... -
Research on Endoplasmic Reticulum Stress-mediated Protective Effect of Melatonin against Cardiotoxicity Following Cisplatin Treatment
Ceylan, Tayfun; Ünsal, Murat; Kaymak, Emin; Akin, Ali Tuğrul; Kuloğlu, Nurhan; Karabulut, Derya; Yakan, Birkan (Medical Journal of Bakirkoy, 2024)Objective: Cisplatin (CP) is a chemotherapeutic drug that causes cardiotoxicity. Melatonin (MEL) is secreted by the pineal gland throughout the night. This study aimed to investigate the protective effect of MEL against ... -
Researches on the protective effect of caffeic acid phenethyl ester on testicular 2 damage caused by cisplatin
BACKGROUND/AIM:Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells and Leydig cells in rat testicles. We aimed to investigate the protective effect of caffeic acid phenethyl ... -
Sisplatin’in Oluşturduğu Testis Hasarı Üzerine Kafeik Asit Fenetil Ester’in Koruyucu Etkisinin İncelenmesi
Ceylan, Tayfun; Kaymak, Emin; Yalçın, Betül; Cantürk Tan, Fazile; Yakan, Birkan (Cell & Tissue Biology Research Turkish, Histology and Embryology Association, 2018)Amaç: Testisler, erkek üreme hücrelerinin üretilmesi evresi olan spermatogenezin gerçekleştiği ve testosteron başta olmak üzere erkek cinsiyet hormonlarının üretildiği yerlerdir. Antikanserojen bir ilaç olan Sisplatin ... -
Sisplatin’in Sıçanlarda Oluşturduğu Böbrek Hasarına Karşı Kafeik Asit Fenetil Ester’in Koruyucu Etkisinin İncelenmesi
Ceylan, Tayfun; Kaymak, Emin; Yakan, Birkan (ZEUGMA II. ULUSLARARASI MULTİDİSİPLİNER ÇALIŞMALAR KONGRESİ, 2019)Amaç: Sisplatin(SP), katı tümörlerin tedavisinde yaygın olarak kullanılan anti-kanserojen bir ilaçtır. SP esas olarak böbrekler tarafından atılır ve ana yan etkilerinden biri nefrotoksisitedir (1). Bu yüzden SP‟in doza ... -
Therapeutic effect of thymoquinone on brain damage caused by nonylphenol exposure in rats
Ceylan, Tayfun; Akin, Ali Tuğrul; Karabulut, Derya; Cantürk Tan, Fazile; Taşkıran, Mehmet; Yakan, Birkan (Journal of Biochemical and Molecular Toxicology, 2023)Nonylphenol (NP), causes various harmful effects such as cognitive impairment and neurotoxicity. Thymoquinone (TQ), has antioxidant, anti-inflammatory, and neuroprotective properties. In this study, our aim is to investigate ...
