PLT - Kitap Bölümü Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/20.500.12695/427

Listeleniyor 1 - 2 / 2

Intermittent Fasting Modulates Age- Dependent Morphological and Histological Hepatic Changes on Liver Tissue in Wistar Rats
(Duvar Yayınevi, 2023) Ceylani, Taha; Tekeli, Hikmet Taner; Eranıl, Işıl; Yılmaz Ertük, Fatma; Keskin, Seda
Abstract Background: Intermittent fasting (IF) plays an essential role in improving age-related cellular degenerative alterations and metabolic diseases. Aim: This study aimed to evaluate the protective effects of IF on aged-related liver degenerations in Wistar albino rats. Material and Methods: In this study, twelve rats were divided into two groups: the Nonfasting Group (12 months) and the Fasting Group (12 months with IF for 35 days). The food access interval of the Fasting group was between 09:00 am and 15:00 pm and their access to food was restricted for 18 hours. At the end of this experiment, all liver sections of groups were stained with H&E and Masson trichrome, and all stained slides were evaluated for histological examination with light microscopy. Results: The results showed that there was a significant increase in inflammations (lobular and portal), spotty necrosis, and ballooning degeneration in the Nonfasting group compared with the Fasting group which had a significant decrease. There was a significant increase in the density of collagen fibers noticed for the Nonfasting group compared to the Fasting group. Conclusion: The anti-inflammatory and antioxidant effects of IF morphological changes may be beneficial in the Fasting group through modulating autophagy in aged liver cells.
Ameliyathanede Cerrahi Örnek (Spesmen) Yönetimi
(Kongre Kitabevi, 2018) Ceylan, Tayfun
Ameliyathanede yönetim organizasyon ve cerrahi uygulamalar

Güncel Gönderiler