Gut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay

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dc.authorid0000-0002-7925-8121
dc.contributor.authorAltuntaş Dönmez, Hamiyet
dc.contributor.authorŞahin Ergül, Serap
dc.contributor.authorAltın Çelik, Pınar
dc.contributor.authorBulut, Kadir
dc.contributor.authorEciroğlu, Hamiyet
dc.contributor.authorÜzen, Ramazan
dc.contributor.authorGüneş Şahin, Gülşah
dc.contributor.authorÖzer, Nurhayat
dc.contributor.authorTemel, Şahin
dc.contributor.authorArıkan, Türkmen Bahadır
dc.contributor.authorEsmaoğlu, Aliye
dc.contributor.authorYüksel, Recep Civan
dc.contributor.authorSungur, Murat
dc.contributor.authorGündoğan, Kürşat
dc.date.accessioned2023-07-14T13:01:46Z
dc.date.available2023-07-14T13:01:46Z
dc.date.issued2023en_US
dc.departmentKapadokya Üniversitesi, Sağlık Bilimleri Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.description.abstractPurpose In an efort to better manage critically ill patients hospitalised in the intensive care unit (ICU) after experiencing multiple traumas, the present study aimed to assess whether plasma levels of intestinal epithelial cell barrier proteins, including occludin, claudin-1, junctional adhesion molecule (JAM-1), tricellulin and zonulin, could be used as novel biomarkers. Additional potential markers such as intestinal fatty acid-binding protein (I-FABP), d-lactate, lipopolysaccharide (LPS) and citrulline were also evaluated. We also aimed to determine the possible relationships between the clinical, laboratory, and nutritional status of patients and the measured marker levels. Methods Plasma samples from 29 patients (frst, second, ffth and tenth days in the ICU and on days 7, 30 and 60 after hospital discharge) and 23 controls were subjected to commercial enzyme-linked immunosorbent assay (ELISA) testing. Results On frst day (admission) and on the second day, plasma I-FABP, d-lactate, citrulline, occludin, claudin-1, tricellulin and zonulin levels were high in trauma patients and positively correlated with lactate, C-reactive protein (CRP), number of days of ICU hospitalisation, Acute Physiology and Chronic Health Evaluation II (APACHE II) score and daily Sequential Organ Failure Assessment (SOFA) scores (P<0.05–P<0.01). Conclusion The results of the present study showed that occludin, claudin-1, tricellulin and zonulin proteins, as well as I-FABP, d-lactate and citrulline, may be used as promising biomarkers for the evaluation of disease severity in critically ill trauma patients, despite the complexity of the analysis of various barrier markers. However, our results should be supported by future studies.
dc.identifier.citationDonmez-Altuntas, H., Sahin Ergul, S., Altin-Celik, P. et al. Gut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay. Eur J Trauma Emerg Surg (2023).
dc.identifier.doi10.1007/s00068-023-02298-6
dc.identifier.urihttps://hdl.handle.net/20.500.12695/2156
dc.identifier.wosWOS:001003911700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.institutionauthorGüneş Şahin, Gülşah
dc.language.isoen
dc.publisherEuropean Journal of Trauma and Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCitrulline
dc.subjectClaudin-1
dc.subjectd-lactate
dc.subjectIntensive care
dc.subjectI-FABP
dc.subjectJAM-1
dc.subjectLPS
dc.subjectOccludin
dc.subjectTricellulin
dc.subjectZonulin
dc.titleGut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay
dc.typeArticle

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