Biodegradable and biocompatible radiopaque iodinated poly-3-hydroxy butyrate: synthesis, characterization and in vitro/in vivo X-ray visibility

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dc.contributor.authorErol, Arzu
dc.contributor.authorRosberg, Derya B. Hazer
dc.contributor.authorHazer, Baki
dc.contributor.authorGoncu, Beyza S.
dc.date.accessioned2020-05-21T01:27:35Z
dc.date.available2020-05-21T01:27:35Z
dc.date.issued2020
dc.departmentKapadokya Ãœniversitesi
dc.descriptionHazer, Baki/0000-0001-8770-805X
dc.descriptionTARAMASCOPUS
dc.descriptionTARAMAWOS
dc.description.abstractSome novel radiopaque biodegradable and biocompatible iodinated polymers based on poly-3-hydroxy butyrate (PHB) were obtained. Following the attachment of diethanol amine to PHB, the hydroxyl ends were capped with 4-iodobenzoic acid and 2,3,5-tri-iodobenzoic acid. In this manner, tri-novel radiopaque polymers were obtained. The resulting polymers were structurally characterized by NMR technique. They were evaluated with respect to their possible use as radiopaque implant biomaterials indicating X-ray visibility in a noninvasive manner using routine X-ray absorption imaging techniques. These polymers exhibited good radiopacity with conventional imaging X-ray techniques in vivo. Additionally, biocompatibility of these iodinated polymers was also evaluated. There were no signs of infection or abscess formation on the surgical area. These novel radiopaque PHBs should be promising biomaterials for a new-generation radiopaque materials.
dc.description.sponsorshipKapadokya University [KUN.2018-BAGP-001]; Bulent Ecevit University Research FundsBulent Ecevit University [BEU-2017-72118496-01]
dc.description.sponsorshipThis work was supported by the Kapadokya University (#KUN.2018-BAGP-001) and Bulent Ecevit University Research Funds (#BEU-2017-72118496-01). The authors thank to Fatih Pekdemir for taking FTIR spectra. This paper has been proofread by Bulent Ecevit University Article Proofreading and Editing Office.
dc.identifier.doi10.1007/s00289-019-02747-6
dc.identifier.endpage289en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-019-02747-6
dc.identifier.urihttps://hdl.handle.net/20.500.12695/29
dc.identifier.volume77en_US
dc.identifier.wosWOS:000511700600016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPoly-3-hydroxy butyrate (PHB)
dc.subjectRadiopaque
dc.subjectBiocompatibility
dc.subjectIn vivo experiment
dc.titleBiodegradable and biocompatible radiopaque iodinated poly-3-hydroxy butyrate: synthesis, characterization and in vitro/in vivo X-ray visibility
dc.typeArticle

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