Effects Of Folic Acid Versus Nicotine On Bone Development

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dc.authorid0000-0002-0249-1435
dc.contributor.authorDoğan, Kadirhan
dc.contributor.authorNisari, Mehtap
dc.contributor.authorPayas, Ahmet
dc.contributor.authorErtekin, Tolga
dc.contributor.authorGüler, Hatice
dc.contributor.authorAl, Özge
dc.date.accessioned2024-07-09T12:09:00Z
dc.date.available2024-07-09T12:09:00Z
dc.date.issued2024en_US
dc.departmentKapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü
dc.description.abstractPurpose: Nicotine exposure during pregnancy directly or indirectly harms not only the mother but also the fetal tissues. The aim of this study is to investigate the possible effects of folic acid given against nicotine used during pregnancy on bone development of fetuses. Materials and Methods: 18 adult female rats were divided into control, low-dose nicotine (LDN), high-dose nicotine (HDN), low-dose nicotine + folic acid (LDN + FA), high-dose nicotine + folic acid (HDN + FA), and folic acid (FA) group equally. During 20 days, 1 ml/kg serum physiologic (SP) solution to the control group, 3 mg/kg nicotine to LDN, 6 mg/kg nicotine to HDN, 3 mg/kg nicotine and 400 µg/kg FA to LDN+FA, 6 mg/kg nicotine and 400 µg/kg FA to HDN+FA, 400 µg/kg FA to the FA group was administered. Bones of fetuses taken by cesarean section on the 20th day of pregnancy were stained with the bilateral skeleton staining technique. The stained anterior and posterior extremity bones were photographed under a stereomicroscope. Bone length, extent of ossification and percentage of ossification were measured. Statistical data were evaluated using the R programming language (v. 3.2.3). Results: The bone development of LDN and HDN groups was significantly lower and LDN+FA and HDN+FA groups was close to the control group (p<0.05). Conclusion: While nicotine used during pregnancy decreases the bone development of fetuses, FA may decrease this effect and increase ossification.
dc.description.sponsorshipErciyes University Scientific Research Project Unit (TYL-2016-6497).
dc.identifier.citationDoğan, K., Nisari, M., Payas, A., Ertekin, T., vd. (2024). Effects Of Folic Acid Versus Nicotine On Bone Development. Ahi Evran Medical Journal, 8(1), 48-55. https://doi.org/10.46332/aemj.1278167
dc.identifier.endpage55en_US
dc.identifier.issn2619 - 9203
dc.identifier.issue1en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://doi.org/10.46332/aemj.1278167
dc.identifier.urihttps://hdl.handle.net/20.500.12695/2780
dc.identifier.volume8en_US
dc.institutionauthorDoğan, Kadirhan
dc.language.isoen
dc.publisherDergi Park
dc.relation.ispartofAhi Evran Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergi
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectossification
dc.subjectrats
dc.subjectskeleton
dc.subjectstaining
dc.titleEffects Of Folic Acid Versus Nicotine On Bone Development
dc.typeArticle

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