The Effects of Active Methamphetamine Use Disorder and Regular Sports Activities on Brain Volume in Adolescents

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dc.contributor.authorYiğit, Hüseyin
dc.contributor.authorGüler, Hatice
dc.contributor.authorTemircan, Zekeriya
dc.contributor.authorGökoğlu, Abdulkerim
dc.contributor.authorÖkçesiz, İzzet
dc.contributor.authorArtar, Müge
dc.contributor.authorDönmez, Halil
dc.contributor.authorUnur, Erdoğan
dc.contributor.authorYılmaz, Halil
dc.date.accessioned2025-07-29T08:59:07Z
dc.date.available2025-07-29T08:59:07Z
dc.date.issued2025
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Anestezi Bölümü
dc.description.abstractObjectives: Methamphetamine (MA) abuse during adolescence can have a significant impact on brain development. On the other hand, regular exercise is known to promote brain health and may have neuroprotective effects. The purpose of this study is to compare brain volumes in three different adolescent groups: those with active methamphetamine use disorder (MUD), adolescent athletes who regularly exercise, and healthy control adolescents. Methods: This MRI study involved three groups of adolescents: 10 with active MUD (9 males, 1 female), nine licensed runner adolescents (three males, six females), and 10 healthy adolescents (5 males, 5 females). Brain volumes were analyzed using T1-weighted images from a 3.0 Tesla MRI scanner, and then segmented automatically with vol2Brain. Statistical analyses included ANCOVA with sex as a covariate and LSD post hoc tests performed using SPSS Statistics 23. Results: Adolescents with MUD showed a 10% increase in total white matter volume compared to the athlete group. Conversely, cortical gray matter volume was reduced by 4% compared to the healthy control group and by 7% compared to the athlete group. The frontal and insular cortices in the MUD group had significantly diminished volumes compared to the athlete group. Overall, individuals with MUD had decreased gray matter volumes and increased white matter volumes in their brains. The brain volumetric differences between the MUD group and the athlete group were statistically significant. Conclusions: The brains of those with MUD displayed a reduction in gray matter volume and an increase in white matter volume, indicating damage from MA on the developing adolescent brain. The volumetric disparities between the MUD and athlete groups were found to be significantly different, suggesting a possible neuroprotective factor of exercise. Further studies are required to explore the potential of exercise-based interventions in alleviating the harmful effects of MA abuse.
dc.identifier.citationYiğit H, Güler H, Temircan Z, Gökoğlu A, Ökçesiz İ, Artar M, Dönmez H, Unur E, Yılmaz H. The Effects of Active Methamphetamine Use Disorder and Regular Sports Activities on Brain Volume in Adolescents. Journal of Clinical Medicine. 2025; 14(15):5212. https://doi.org/10.3390/jcm14155212
dc.identifier.doihttps://doi.org/10.3390/jcm14155212
dc.identifier.urihttps://hdl.handle.net/20.500.12695/3707
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorYiğit, Hüseyin
dc.institutionauthorid0000-0002-7739-9844
dc.language.isoen
dc.publisherJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe Effects of Active Methamphetamine Use Disorder and Regular Sports Activities on Brain Volume in Adolescents
dc.typeArticle

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