The Dose-Dependent Effects Of Doxorubicin In Ratliver Tissue

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dc.authorid0000-0002-0917-0378
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorKaymak, Emin
dc.contributor.authorKarabulut, Derya
dc.contributor.authorDoğanyiğit, Züleyha
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorToluk, Ayşe
dc.contributor.authorÖzdamar, Saim
dc.date.accessioned2020-07-07T11:24:19Z
dc.date.available2020-07-07T11:24:19Z
dc.date.issued2019en_US
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Patoloji Laboratuvar Teknikleri Bölümü
dc.description.abstractIntroduction: Doxorubicin (DOX) is an anthracycline antibiotic used as an anticancer agent and is a widely used chemotherapeutic for many cancer types such as sarcoma, acute lymphoblastic leukaemia and as well as breast and liver cancers. Recently, it has been shown that DOX causes hepatic toxicity. Toxic effects of DOX are associated with increased formation of reactive oxygen species (ROS), releasing of pro-inflammatory cytokines and induction of apoptotic and necrotic changes in organs. The aim of this study is determine of dose-dependent effects of DOX on inflammation in rat liver tissue. Methods: 30 male rats were assigned to the following groups: Group I as controls, Group II was given Chronic DOX i.p. (2 mg/kg/BW) a total of 10 times, once every three days. Groups III, Acute DOX group which received DOX (15 mg/kg BW) single dose as the intraperitoneal the 20th day of the study. On the 28th day of the experiment, under anesthesia by ether, livers of animals were obtained for histopathological and immunohistochemical evaluation. Sections of 5 ?m thick were sliced with a microtome and stained with hematoxylin and eosin. TNF-alpha and IL-6 were detected immunohistochemically using a polyclonal antibody and the streptavidin–biotin–peroxidase technique. Results: In this study, injection of both DOX Chronic (2mg/kg) and DOX Acute (15 mg/kg) triggered a significant elevation of the liver damage. Hepatic sections of the rats treated with chronic and acute DOX groups were seen intracellular cell degeneration, intracytoplasmic vacuoles, haemorrhage and picnotic cells. IL-6 immunreactivity was significantly increased in chronic group and acute group compared to control group. TNFalpha immunreactivity was significantly increased in chronic group compared to control group. Conclusion: Our results demonstrated that chronically administered doxorubicin increases liver damage. In conclusion, it may be advisable to increase studies on the use of chronic doses in combination of antiinflammatory agents.
dc.identifier.urihttps://hdl.handle.net/20.500.12695/653
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.publisher1st International Ahi Evran Medical and Health Science Congress (IAMHC)
dc.relation.ispartof1st International Ahi Evran Medical and Health Science Congress (IAMHC)
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectDoxorubicin
dc.subjectLiver damage
dc.subjectHepatotoxicity
dc.subjectİnflammation.
dc.titleThe Dose-Dependent Effects Of Doxorubicin In Ratliver Tissue
dc.typeConference Object

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