Effects of pseudoephedrine on rat fetal bone development: evaluation by three different methods

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dc.authoridhttps://orcid.org/0000-0002-7739-9844
dc.authorid0000-0002-7739-9844
dc.contributor.authorYiğit, Hüseyin
dc.contributor.authorBalcıoğlu, Esra
dc.contributor.authorUçar, İlyas
dc.contributor.authorDeğermenci, Muhammet
dc.contributor.authorÖnder, Gözde Özge
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorUnur, Erdoğan
dc.date.accessioned2023-07-18T14:17:51Z
dc.date.available2023-07-18T14:17:51Z
dc.date.issued2023en_US
dc.departmentKapadokya Üniversitesi
dc.description.abstractPseudoephedrine (PSE) is an agent that is contained in common cold medications. The agent, which is used to treat cold and cough, is the fourth most prescribed drug group in some countries. During pregnancy, expectant mothers use PSE for colds and other reasons. One out of every four expectant mothers use PSE alone or in combination with other medicines for various reasons. This study was aimed to investigate effects of PSE on long bones development in rat during fetal growth. Pregnant rats were divided into five groups: control and four experimental groups (25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg PSE). Between 1 and 20 days of pregnancy, PSE was given to them by gavage. Weights and heights of fetuses isolated by cesarean on the 21st day were measured. Ossification of femur and humerus was examined by three different methods mentioned earlier. Depending on the dose increase, all morphometric data, ossification rate and bone length of the fetuses were decreased. Besides, it was determined that the amount of Calcium in the bone tissue decreased in the analyzes made with SEM–EDX Analysis. The data obtained from this study reveal that the use of PSE during pregnancy disrupts the existing balance in the bone and negatively affects ossification due to the dose increase. In conclusion, we present descriptive and novel data on the effects of PSE use during pregnancy on the bone development of rat fetal long bones.
dc.description.sponsorshipErciyes University TYL-2018-7924
dc.identifier.doi10.1007/s12565-023-00733-7
dc.identifier.endpage11en_US
dc.identifier.isbn1447-6959
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1007/S12565-023-00733-7
dc.identifier.urihttps://hdl.handle.net/20.500.12695/2160
dc.identifier.wosWOS:001017820200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Sceince
dc.institutionauthorYiğit, Hüseyin
dc.language.isoen
dc.publisherSPRINGER
dc.relation.ispartofANATOMICAL SCIENCE INTERNATIONAL
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergi
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectEDX analysis
dc.subjectMorphology
dc.subjectOssification
dc.subjectSEM
dc.subjectTeratology
dc.titleEffects of pseudoephedrine on rat fetal bone development: evaluation by three different methods
dc.typeArticle

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