Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions

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dc.authorid0000-0002-0917-0378
dc.contributor.authorYıldırım, Ayşegül Burçin
dc.contributor.authorDeğer, Necla
dc.contributor.authorSayan, Meryem
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorKaymak, Emin
dc.contributor.authorKara, Mehmet
dc.contributor.authorÜnsal, Murat
dc.contributor.authorKarabulut, Derya
dc.date.accessioned2023-10-26T10:17:57Z
dc.date.available2023-10-26T10:17:57Z
dc.date.issued2023en_US
dc.departmentKapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü
dc.description.abstractThis study aimed to determine whether thymoquinone has any protective effects on renal tissue after an isoproterenol-induced myocardial infarction (MI). Experimental groups were formed as 4 groups (n=8). Control group (C). Thymoquinone group (THQ), 20 mg/kg single dose intragastric (i.g.) daily for seven days. Isoproterenol group (ISO) was administered 100 mg/kg intraperitoneally in two doses on days 7 and 8 of the experiment. Thymoquinone+Isoproterenol group (THQ+ISO), THQ 20 mg/kg i.g. was administered once a day for seven days. In addition, two doses of ISO 100 mg/kg i.p. were administered on the seventh and eighth days. Kidney tissues were evaluated histopathologically. Kidney tissues were evaluated histopathologically. Tumour necrosis factor alpha(TNF-?) and alpha Smooth Muscle Actin(?-SMA) immunoreactivity density changes were determined by immunohistochemistry. Glutathione(GST), Glutathione S-transferases(GSTs) and Interleukin-6(IL-6) levels were evaluated by ELISA method. Isoproterenol injection caused severe histopathological changes on kidney tissue. Also TNF-? and ?-SMA levels were found to be higher in groups where ISO was administered. THQ could be effective on kidney tissue to partially correct these histopathological damages, by decreasing fibrosis and inflammation. This study shows that treatment with THQ is effective in preventing kidney damage caused by ISO-induced MI. We think that THQ as a supplementary food will be effective to prevent kidney damage.
dc.identifier.citationYıldırım A. B. , Değer N. , Sayan M. , Akın A. , Ceylan T. , Kaymak E. , Kara M. , Ünsal M. , Karabulut D. Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions. Experimental and Applied Medical Science. 2023; 4(2): 515-525.
dc.identifier.endpage525en_US
dc.identifier.issue2en_US
dc.identifier.startpage515en_US
dc.identifier.urihttps://doi.org/10.46871/eams.1359212
dc.identifier.urihttps://hdl.handle.net/20.500.12695/2295
dc.identifier.volume4en_US
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.publisherExperimental and Applied Medical Science
dc.relation.ispartofExperimental and Applied Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIsoproterenol
dc.subjectThymoquinone
dc.subjectInflamation
dc.subjectFibrosis
dc.subjectKidney
dc.titleInvestigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions
dc.typeArticle

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