Comparison of the Acute and Cumulative Dose Administrations in Doxorubicin-induced Hepatotoxicity via Evaluation of the Histopathological Changes and Inflammation in Rats

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dc.authorid0000-0002-0917-0378
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorKaymak, Emin
dc.contributor.authorKarabulut, Derya
dc.contributor.authorDoğanyiğit, Züleyha
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorToluk, Ayşe
dc.contributor.authorÖzdamar, Saim
dc.date.accessioned2021-03-10T11:19:15Z
dc.date.available2021-03-10T11:19:15Z
dc.date.issued2020en_US
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Patoloji Laboratuvar Teknikleri Bölümü
dc.description.abstractDoxorubicin (DOX) may lead to hepatotoxicity when administered chronically or in a high dose. The aim of this study is to determine dose–dependent effects of DOX in rat liver tissue. Thirty male Wistar albino rats were divided into three groups; group I as control, group II as receiving chronically DOX (2 mg/kg, twice in a week, total 20 mg/kg, intraperitoneally) and group III as receiving an acute–single dose of DOX (15 mg/kg, intraperitoneally, on the 20th day) administered groups. At the end of 30th day, animals were sacrificed, and liver tissues were extracted for histopathological and immunohistochemical evaluation. Sections were stained with hematoxylin & eosin to evaluate the histopathological changes and TNF-? and IL-6 expressions were detected by immunohistochemical staining. Both chronic and acute administrations of DOX triggered a significant liver damage. However, it was observed that liver damage induced by acute–single dose DOX administrations were higher than those induced by chronic DOX administrations. TNF-? and IL-6 immunoreactivity was significantly increased in both group II and III group compared to control group. However, immunoreactivity of TNF-? was substantially higher in the group III compared to control. These results demonstrated that acute administrations of DOX relatively induce serious liver damage and inflammatory response.
dc.identifier.citationAli, A. K. I. N., Kaymak, E., Karabulut, D., Doğanyiğit, Z., Ceylan, T., Toluk, A., & Özdamar, S. Comparison of the acute and cumulative dose administrations in doxorubicin-induced hepatotoxicity via evaluation of the histopathological changes and inflammation in rats. Experimental and Applied Medical Science, 1(3), 73-81.
dc.identifier.endpage81en_US
dc.identifier.issue3en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.46871/eams.2020.10
dc.identifier.urihttps://hdl.handle.net/20.500.12695/991
dc.identifier.volume1en_US
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.publisherExperimental and Applied Medical Science
dc.relation.ispartofExperimental and Applied Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDoxorubicin
dc.subjectHepatotoxicity
dc.subjectInflammation
dc.subjectLiver damage
dc.titleComparison of the Acute and Cumulative Dose Administrations in Doxorubicin-induced Hepatotoxicity via Evaluation of the Histopathological Changes and Inflammation in Rats
dc.typeArticle

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