Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway

Basit Öğe Kaydı
dc.authorid0000-0002-0917-0378
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorKaymak, Emin
dc.contributor.authorVarinli, Şaban
dc.contributor.authorToluk, Ayşe
dc.date.accessioned2024-06-05T07:02:09Z
dc.date.available2024-06-05T07:02:09Z
dc.date.issued2024en_US
dc.departmentKapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü
dc.description.abstractBackground and Purpose: The most significant pathogen hypothesized to be causing the formation of Acute lung injury (ALI) in sepsis is thought to be lipopolysaccharide (LPS), a key endotoxin component of gram-negative bacteria. The main objective of this study is to determine possible anti-inflammatory effects of crocin (CRO) which has many biological properties such as anti-inflammatory, antioxidant, and anti-apoptotic in LPS-induced ALI. Methods: 40 Wistar albino rats were divided into four groups: Control (no treatment), CRO (given 50 mg/kg crocin for 9 days), LPS (given 30 mg/kg LPS at 9th day), LPS+CRO (given 50 mg/kg crocin for 9 days and 30 mg/kg LPS at 9th day). After experimental, rats were sacrificed and lungs were extracted. Histological examinations were performed in the lung tissue and the changes in the HMGB1 and TLR4 expressions were determined via immunohistochemical staining. Results and Conclusion: Hemorrhage, mononuclear cell infiltration and HMGB1 and TLR4 expressions significantly increased in the LPS group. However, CRO administrations exerted a strong protective effect on the lungs in terms of these parameters in LPS+CRO group. According to our results, we suggest that CRO can be considered as a protective agent against LPS induced ALI via inhibition of HMGB1/TLR4 pathway-mediated inflammatory response.
dc.identifier.citationCeylan T, Akin A T, Kaymak E, Varinli S, Toluk A. Crocin Suppresses Inflammatory Response in LPSInduced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway. J Basic Clin Health Sci 2024; 8:271-278.
dc.identifier.endpage278en_US
dc.identifier.issue2en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.30621/jbachs.1233245
dc.identifier.urihttps://hdl.handle.net/20.500.12695/2762
dc.identifier.volume8en_US
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.publisherDergiPark
dc.relation.ispartofJournal of Basic and Clinical Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute lung injury
dc.subjectCrocin
dc.subjectInflammation
dc.subjectLipopolysaccharide
dc.titleCrocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway
dc.title.alternativeCrocin prevents lung damage caused by LPS
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1-TLR4 Inflammation Pathway.pdf
Boyut:
7.92 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale / Article
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

DH - Makale Koleksiyonu