Effect of the hypothalamic serotonin on body weight change in the context of brain insulin resistance in Alzheimer’s disease
| dc.contributor.author | Ebru | |
| dc.date.accessioned | 2026-06-17T05:53:50Z | |
| dc.date.available | 2026-06-17T05:53:50Z | |
| dc.date.issued | 16/06/2026 | |
| dc.department | Kapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü | |
| dc.description.abstract | Aims: The present work was designed to evaluate how alterations in serotonin (5-hydroxytryptamine, 5-HT), 5-HT receptor subtype 2B (5-HT2BR), and neuropeptide Y (NPY) are associated with body weight regulation in a rat model of brain insulin resistance (B-IR) that mimics the early pathological features of Alzheimer’s disease (AD). Methods: B-IR was induced in rats through intracerebroventricular (i.c.v.) administration of amyloid-β₁–₄₂ oligomers at a dose of 2.5 nmol in a total volume of 10 μL. 5-HT concentrations were quantified in brainstem and hypothalamic samples, while hypothalamic levels of 5-HT2BR and NPY were determined using enzyme-linked immunosorbent assay (ELISA) methods. Body weight variation for each animal was defined as the difference between post-experimental and initial measurements. Group comparisons were conducted using the Mann–Whitney U test, and statistical significance was accepted at p < 0.05. Results: Rats in the B-IR group showed a tendency toward increased 5-HT levels in brainstem tissue compared to the control group (p > 0.05), whereas hypothalamic 5-HT levels were significantly decreased in the B-IR group compared to controls (p < 0.01); body weight was significantly reduced in the B-IR group compared to the control group (p<0.01). In addition, rats in the B-IR group showed a downward trend in hypothalamic 5-HT2BR and NPY levels compared with the control group (p > 0.05 for both). Conclusion: These findings suggest that decreased hypothalamic 5-HT levels in the B-IR group may be associated with the observed reduction in body weight. Additionally, the downward trends observed in 5-HT2BR and NPY levels may also be related to this change. | |
| dc.identifier.citation | Effect of the hypothalamic serotonin on body weight change in the context of brain insulin resistance in Alzheimer’s disease Ebru Afşar * Open Access June 16, 2026 Page 120-126 | |
| dc.identifier.doi | https://doi.org/10.66235/kumj.1853640 | |
| dc.identifier.endpage | 126 | |
| dc.identifier.issue | 2 | |
| dc.identifier.startpage | 120 | |
| dc.identifier.trdizinid | TX... | |
| dc.identifier.uri | https://doi.org/10.66235/kumj.1853640 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12695/4189 | |
| dc.identifier.volume | 6 | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.institutionauthor | Afşar, Ebru | |
| dc.institutionauthorid | 0000-0002-7817-855X | |
| dc.language.iso | en | |
| dc.publisher | Kastamonu Medical Journal | |
| dc.relation.publicationcategory | Makale - Ulusal - Editör Denetimli Dergi | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.title | Effect of the hypothalamic serotonin on body weight change in the context of brain insulin resistance in Alzheimer’s disease | |
| dc.type | Article |
