Therapeutic effect of thymoquinone on brain damage caused by nonylphenol exposure in rats

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dc.authorid0000-0002-0917-0378
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorAkin, Ali Tuğrul
dc.contributor.authorKarabulut, Derya
dc.contributor.authorCantürk Tan, Fazile
dc.contributor.authorTaşkıran, Mehmet
dc.contributor.authorYakan, Birkan
dc.date.accessioned2023-07-24T10:09:55Z
dc.date.available2023-07-24T10:09:55Z
dc.date.issued2023en_US
dc.departmentKapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü
dc.description.abstractNonylphenol (NP), causes various harmful effects such as cognitive impairment and neurotoxicity. Thymoquinone (TQ), has antioxidant, anti-inflammatory, and neuroprotective properties. In this study, our aim is to investigate the effects of TQ on the brain damage caused by NP. Corn oil was applied to the control group. NP (100 mg/kg/day) was administered to the NP and NP + TQ groups for 21 days. TQ (5 mg/kg/day) was administered to the NP + TQ and TQ groups for 7 after 21 days. At the end of the experiment, the new object recognition test was applied to the rats and the rats were killed and their brain tissues were removed. Sections taken from brain tissues were stained with hematoxylin-eosin for histopathological evaluation. In addition, neuronal nuclei (NeuN), glial fibrillary acidic protein (GFAP), Cas-3, and nerve growth factor (NGF) immunoreactivities were evaluated in brain tissue sections. In addition, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) activities were determined. Comet assay was applied to determine DNA damage in cells. The results of our study showed that NP, caused behavioral disorders and damage to the cerebral cortex in rats. This damage in the form of neuron degeneration seen in the cortex was associated with apoptosis involving Cas-3 activation, increased DNA damage, and free oxygen radicals. NP, SOD, and CAT caused a decrease in enzyme activities. In addition, the cellular protein NeuN was decreased, astrocytosis-associated GFAP was increased, and growth factor NGF was decreased. When all our evaluations are taken together, treatment with TQ showed an ameliorative effect on the behavioral impairment and brain damage caused by NP exposure.
dc.identifier.citationCeylan, T., Akin, A. T., Karabulut, D., Tan, F. C., Taşkiran, M., & Yakan, B. (2023). Therapeutic effect of thymoquinone on brain damage caused by nonylphenol exposure in rats. Journal of Biochemical and Molecular Toxicology, e23471.
dc.identifier.doi10.1002/jbt.23471
dc.identifier.urihttps://doi.org/10.1002/jbt.23471
dc.identifier.urihttps://hdl.handle.net/20.500.12695/2178
dc.identifier.wosWOS:001028700300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.institutionauthorCeylan, Tayfun
dc.language.isoen
dc.publisherJournal of Biochemical and Molecular Toxicology
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant
dc.subjectBehavioral impairment
dc.subjectBrain damage
dc.subjectNonylphenol
dc.subjectThymoquinone
dc.titleTherapeutic effect of thymoquinone on brain damage caused by nonylphenol exposure in rats
dc.typeArticle

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