How does zinc chelation affect liver sphingolipid metabolism in an Alzheimer's-like model?

Basit Öğe Kaydı
dc.authorid0000-0002-7817-855X
dc.contributor.authorEbru, Afşar
dc.contributor.authorKantar Gül, Deniz
dc.date.accessioned2025-01-28T12:07:06Z
dc.date.available2025-01-28T12:07:06Z
dc.date.issued2025en_US
dc.departmentKapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü
dc.description.abstractBackground: The present study aimed to evaluate the impact of Cyclo-Z, a combination of Cyclo (His-Pro) plus zinc, on hepatic sphingolipid (SL) metabolism and antioxidant properties in a rat model of Alzheimer's disease (AD). Methods: Alzheimer's disease rat model created via intracerebroventricular (i.c.v.) amyloid beta-42 oligomer (A?O) injection into the lateral ventricles. Cyclo-Z administration was performed with daily gavage for 3 weeks after the A?O injection. Ceramide, ceramide kinase (CERK), sphingosine 1 phosphate (S1P), glutathione (GSH), total oxidant capacity (TOS), 4-hydroxynonenal (HNE) and caspase-3 levels were measured with Elisa kit in liver tissue. Results: S1P, CERK and GSH levels increased and ceramide, TOS, 4 HNE, and caspase-3 levels decreased in the liver tissues of AD group. Cyclo-Z treatment decreased S1P, CERK, ceramide and caspase-3 levels but increased TOS and 4-HNE levels in the liver tissues of AD group. Conclusion: These results showed that SL metabolism was modulated to generate an anti-apoptotic defense system in liver tissue of AD rats.
dc.description.sponsorshipKültür Üniversitesi
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/39809015/
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2025.127589
dc.identifier.urihttps://hdl.handle.net/20.500.12695/3160
dc.institutionauthorAfşar, Ebru
dc.language.isoen
dc.publisherELSEVIER
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's disease
dc.subjectCeramide
dc.subjectSphingosine 1 phosphate
dc.subjectZinc
dc.titleHow does zinc chelation affect liver sphingolipid metabolism in an Alzheimer's-like model?
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Q2 Yayın tam metni.pdf
Boyut:
2.15 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale / Article
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diş Hekimliği - Makale Koleksiyonu