The Effect of Pituitary Neuroendocrine Tumors on the Volumes of Intracranial Structures

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dc.contributor.authorGökoğlu, Abdulkerim
dc.contributor.authorYiğit, Hüseyin
dc.contributor.authorYolaçan, Ebru
dc.contributor.authorNisari, Mehtap
dc.contributor.authorUnur, Erdoğan
dc.contributor.authorSelçuklu, Ahmet
dc.date.accessioned2025-07-29T08:59:38Z
dc.date.available2025-07-29T08:59:38Z
dc.date.issued2025
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Anestezi Bölümü
dc.description.abstractObjective: Pituitary Neuroendocrine Tumors (PitNETs) can cause symptoms via mass effect or hormonal imbalances. This study investigated whether PitNETs induce volumetric changes in intracranial structures and assessed the diagnostic potential of these changes.Material and Methods: A retrospective analysis was conducted on 90 PitNET patients and 86 healthy controls. MRI data, acquired on a 1.5 Tesla scanner, were processed using the automated Vol2Brain system to calculate relative brain volumes.Results: PitNET patients exhibited significantly lower relative volumes across numerous brain structures compared to controls. This included reduced intracranial, cerebral, and cortical gray matter (GM), as well as temporal lobe, vermis, limbic lobe, hippocampus, and inferior lateral ventricle (ILV) volumes. Gyrus-level analysis also revealed significantly smaller volumes in key regions like the posterior orbital gyrus, supplementary motor cortex, and entorhinal area in PitNET patients. ROC analysis demonstrated good to very good diagnostic performance for ILV volume (AUC=0.863; p=0.002) and subcortical GM volume (AUC=0.725; p=0.049) in differentiating groups. Reduced volumes were also noted in basal ganglia structures.Conclusions: Our findings indicate significant volumetric reductions in various brain regions in PitNET patients, potentially explaining observed emotional and cognitive symptoms. The diagnostic utility of ILV and subcortical GM volumes is promising, suggesting their value as diagnostic adjuncts. These objective volumetric assessments may assist in surgical planning and patient stratification, though further prospective research is warranted to establish direct links with clinical outcomes.
dc.identifier.citationGökoğlu, A., Yiğit, H., Yolacan, E., Nisari, M., Unur, E., Selçuklu, A. (2025) “The Effect of Pituitary Neuroendocrine Tumors on the Volumes of Intracranial Structures”, Frontiers in Neurology, (in press)
dc.identifier.doi10.3389/fneur.2025.1585921/abstract
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12695/3708
dc.identifier.volume16
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.institutionauthorHüseyin
dc.institutionauthorid0000-0002-7739-9844
dc.language.isoen
dc.publisherFrontiers in Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleThe Effect of Pituitary Neuroendocrine Tumors on the Volumes of Intracranial Structures
dc.typeArticle

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