Does Zn-mediated regulation of the kynurenine pathway provide the link between periodontal disease and diabetes?

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dc.authorid0000-0002-7817-855X
dc.authorid0000-0002-0249-1435
dc.contributor.authorAfşar, Ebru
dc.contributor.authorDoğan, Kadirhan
dc.contributor.authorArslan, Erdem
dc.contributor.authorEranıl, Işıl
dc.contributor.authorOral, Neşe
dc.contributor.authorKuzzu, Bahadır Kadir
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorÖz, Mehmet
dc.date.accessioned2025-11-21T08:38:32Z
dc.date.available2025-11-21T08:38:32Z
dc.date.issued2025-07
dc.departmentKapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü
dc.description.abstractIt has long been known that there is a relationship between periodontal diseases and diabetes. The present study aimed to assess the effect of pancreatic zinc (Zn) levels on Kynurenin pathways (KP) and glucose homeostasis and the impact of Thymoquinone (TQ) in the periodontal disease animal model. Methods: 10 µl Porphyromonas gingivalis-Lipopolysaccharide (P. gingivalis-Lps) (1mg/ml) was injected at 48-hour intervals into the palatal gingiva of rats, and TQ was given by oral gavage (10 mg/kg per day) for 2 weeks. Glucose homeostasis was assessed using the Homeostatic Model Assessment (HOMA-IR), and β-cell function (HOMA-β Levels). Kynurenine (KYN), Tryptophan (TRP), kynurenic acid (KYNA), quinolinic acid (QA), KYN 3-monooxygenase (KMO), kynureninase, interferon-γ (IFN-γ), insulin, ZIP10, and caspase-3 levels measured by the enzyme-linked immunosorbent assay (ELISA). Zinc levels in the pancreas tissue and plasma samples were measured using a colorimetric method. Morphological changes in the pancreas were identified by hematoxylin and eosin staining, and X-ray radiography determined bone resorption in the maxillary bone. Results: In the LPS group, pancreas ZIP10 and Zn levels increased, the KP pathway was altered to favor KYNA, and impaired glucose homeostasis was observed. TQ administration decreased pancreatic Zn levels, changed KP to favor QA, and improved morphological changes in the pancreas. Conclusion: During the progression of periodontal diseases, KP may be altered by Zn levels through ZIP10 in the pancreas, thereby impairing pancreatic function. Regulation of Zn levels may be key to shared pathways between periodontal diseases and diabetes.
dc.identifier.doi10.21203/rs.3.rs-6641065/v1
dc.identifier.urihttps://hdl.handle.net/20.500.12695/3850
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAfşar, Ebru
dc.institutionauthorDoğan, Kadirhan
dc.institutionauthorEranıl, Işıl
dc.institutionauthorOral, Neşe
dc.institutionauthorCeylan, Tayfun
dc.institutionauthorid0000-0002-7817-855X
dc.institutionauthorid0000-0002-0249-1435
dc.language.isoen
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleDoes Zn-mediated regulation of the kynurenine pathway provide the link between periodontal disease and diabetes?
dc.typeArticle

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