Intermittent Fasting Modulates Age- Dependent Morphological and Histological Hepatic Changes on Liver Tissue in Wistar Rats
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Tarih
2023
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Yayıncı
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Abstract Background: Intermittent fasting (IF) plays an essential role in improving age-related cellular degenerative alterations and metabolic diseases. Aim: This study aimed to evaluate the protective effects of IF on aged-related liver degenerations in Wistar albino rats. Material and Methods: In this study, twelve rats were divided into two groups: the Nonfasting Group (12 months) and the Fasting Group (12 months with IF for 35 days). The food access interval of the Fasting group was between 09:00 am and 15:00 pm and their access to food was restricted for 18 hours. At the end of this experiment, all liver sections of groups were stained with H&E and Masson trichrome, and all stained slides were evaluated for histological examination with light microscopy. Results: The results showed that there was a significant increase in inflammations (lobular and portal), spotty necrosis, and ballooning degeneration in the Nonfasting group compared with the Fasting group which had a significant decrease. There was a significant increase in the density of collagen fibers noticed for the Nonfasting group compared to the Fasting group. Conclusion: The anti-inflammatory and antioxidant effects of IF morphological changes may be beneficial in the Fasting group through modulating autophagy in aged liver cells.
Açıklama
Anahtar Kelimeler
Aging, inflammation, intermitted fasting, liver, histopathology
Kaynak
New Frontiers in Health Sciences
WoS Q Değeri
Scopus Q Değeri
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Sayı
125
