Intermittent Fasting Modulates Age- Dependent Morphological and Histological Hepatic Changes on Liver Tissue in Wistar Rats

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dc.authorid0000 0001 9557 8523
dc.contributor.authorCeylani, Taha
dc.contributor.authorTekeli, Hikmet Taner
dc.contributor.authorEranıl, Işıl
dc.contributor.authorYılmaz Ertük, Fatma
dc.contributor.authorKeskin, Seda
dc.date.accessioned2024-02-15T13:27:06Z
dc.date.available2024-02-15T13:27:06Z
dc.date.issued2023en_US
dc.departmentKapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Patoloji Laboratuvar Teknikleri Bölümü
dc.description.abstractAbstract Background: Intermittent fasting (IF) plays an essential role in improving age-related cellular degenerative alterations and metabolic diseases. Aim: This study aimed to evaluate the protective effects of IF on aged-related liver degenerations in Wistar albino rats. Material and Methods: In this study, twelve rats were divided into two groups: the Nonfasting Group (12 months) and the Fasting Group (12 months with IF for 35 days). The food access interval of the Fasting group was between 09:00 am and 15:00 pm and their access to food was restricted for 18 hours. At the end of this experiment, all liver sections of groups were stained with H&E and Masson trichrome, and all stained slides were evaluated for histological examination with light microscopy. Results: The results showed that there was a significant increase in inflammations (lobular and portal), spotty necrosis, and ballooning degeneration in the Nonfasting group compared with the Fasting group which had a significant decrease. There was a significant increase in the density of collagen fibers noticed for the Nonfasting group compared to the Fasting group. Conclusion: The anti-inflammatory and antioxidant effects of IF morphological changes may be beneficial in the Fasting group through modulating autophagy in aged liver cells.
dc.identifier.issue125en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12695/2615
dc.institutionauthorEranıl, Işıl
dc.language.isotr
dc.publisherDuvar Yayınevi
dc.relation.ispartofNew Frontiers in Health Sciences
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAging
dc.subjectinflammation
dc.subjectintermitted fasting
dc.subjectliver
dc.subjecthistopathology
dc.titleIntermittent Fasting Modulates Age- Dependent Morphological and Histological Hepatic Changes on Liver Tissue in Wistar Rats
dc.typeBook Chapter

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