EFFECT OF BEE BREAD ON LIVER 5HT2B-MEDIATED GLUCOSE REGULATION IN ALZHEIMER'S RAT MODEL
| dc.authorid | 0000-0002-7817-855X | |
| dc.contributor.author | Afşar, Ebru | |
| dc.contributor.author | Doğan, Kadirhan | |
| dc.contributor.author | Kantar Gül, Deniz | |
| dc.contributor.author | Kuzzu, Alev Duygu | |
| dc.date.accessioned | 2025-01-28T12:10:49Z | |
| dc.date.available | 2025-01-28T12:10:49Z | |
| dc.date.issued | 2024 | en_US |
| dc.department | Kapadokya Üniversitesi, Diş Hekimliği Fakültesi, Diş Hekimliği Bölümü | |
| dc.description.abstract | OBJECTIVE: This study aimed to examine the effect of bee bread on glucose regulation and weight change through the change of insulin, serotonin (5-hydroxytryptamine, 5-HT), and leptin hormones in the rat model of Alzheimer's disease (AD). | |
| dc.description.abstract | MATERIAL AND METHODS: Alzheimer's disease rat model created via intracerebroventricular (i.c.v.) Streptozotocin (STZ) injection into the lateral ventricles. Beebread administration was performed with daily gavage for three weeks after the STZ injection. Leptin, İnsulin, 5-HT levels in plasma and leptin, insulin, 5-HT, 5HT receptor 2B (5HT2B), glucose transporter 2 (GLUT2), glucose 6-phosphatase (G6pase) levels in liver tissue were measured with Elisa kit. Fasting blood glucose levels were measured using a glucometer, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) levels were calculated using the formula. Each rat's weight change was calculated by subtracting their initial weight from their final weight. | |
| dc.description.abstract | RESULTS: In the AD-created rats, ıt was observed that blood glucose, plasma insulin, and HOMA-IR levels, liver 5-HT, plasma 5-HT, and leptin levels decreased, liver 5-HT2B and GLUT-2, and weight loss increased. In the AD-created rats, bee bread treatment significantly increased liver 5-HT2B, liver G6pase levels, and plasma leptin levels, also markedly increased plasma 5-HT, liver 5-HT, GLUT-2, and weight loss levels, and decreased fasting blood glucose levels without affecting plasma insülin levels in the AD group. | |
| dc.description.abstract | CONCLUSIONS: These results showed that glucose metabolism was modulated to generate an anti-diabetic defense system in the liver tissue of AD-created rats. Beebread administration reduced fasting blood glucose levels by increasing leptin-mediated insulin sensitivity in the AD-created rats. | |
| dc.description.sponsorship | KAPADOKYA ÜNİVERSİTESİ | |
| dc.identifier.endpage | 475 | en_US |
| dc.identifier.startpage | 466 | en_US |
| dc.identifier.uri | https://dergipark.org.tr/tr/pub/kocatepetip/issue/87739/1433727 | |
| dc.identifier.uri | https://doi.org/10.18229/kocatepetip.1433727 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12695/3161 | |
| dc.identifier.volume | 25 | en_US |
| dc.institutionauthor | Afşar, Ebru | |
| dc.institutionauthor | Doğan, Kadirhan | |
| dc.language.iso | en | |
| dc.publisher | ULAKBİM | |
| dc.relation.ispartof | Kocatepe Tıp Dergisi | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Alzheimer hastalığı, Karaciğer, Arı Ek-meği, 5-HT2B, Leptin. | |
| dc.subject | Alzheimer's disease, Liver, Bee Bread, 5-HT2B, Leptin | |
| dc.title | EFFECT OF BEE BREAD ON LIVER 5HT2B-MEDIATED GLUCOSE REGULATION IN ALZHEIMER'S RAT MODEL | |
| dc.title.alternative | ARI EKMEĞİNİN ALZHEİMER SIÇAN MODELİNDE KARACİĞER 5HT2B ARACILI GLUKOZ DÜZENLEMESİ ÜZERİNE ETKİSİ | |
| dc.type | Article |
